The Hoesch reaction or Houben-Hoesch reaction is a chemical reaction in which a nitrile reacts with an arene compound to give an aryl ketone. The reaction is a kind of Friedel-Crafts acylation with hydrochloric acid and a Lewis acid catalyst.
An illustration is the synthesis of 1-(2,4, 6-Trihydroxyphenyl)ethanone from phloroglucinol:
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