The Haber-Weiss reaction produces •OH (hydroxyl radicals) from H₂O₂ (hydrogen peroxide) and superoxide (•O2-). This reaction can takes place in cells and is thus a likely source for oxidative stress. The reaction is extremely slow, but is catalyzed by iron. The first step of the catalytic cycle includes reduction of ferric ion to ferrous:

Fe³⁺ + •O₂- → Fe²⁺ + O₂

The second step is known as Fenton reaction:

Fe²⁺ + H₂O₂ → Fe³⁺ + OH^- + •OH

Net reaction:

• O^2- + H₂O₂ → OH + OH^- + O₂

The reaction is named for the Fritz Haber and his student Joseph Joshua Weiss.

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