The Gould-Jacobs reaction is a chemical organic synthesis for the formation of quinolines. In this reaction aniline or an aniline derivative initially reacts with malonic acid derivative ethyl ethoxymethylenemalonate with substitution of the ethoxy group through nitrogen. A benzannulation occurs by application of heat to quinoline. The ester group is hydrolysed through sodium hydroxide to the carboxylic acid and decarboxylation again by application of heat to 4-hydroxyquinoline.
An illustration is the synthesis of 4,7-dichloroquinoline
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