Degree of dispersion of protein solution is decreased.

It is decreased because of certain reasons:-

• Association: refers to changes occuring at subunit or molecular level.
• Polymerization or aggregation: involves formation of large complexes.
• Precipitation: includes all aggregation reactions with total loss of solubility.
• Flocculation: random aggregation reaction in the absence of denaturation; often occurs because of suppression of electrostatic repulsion between the chains.
• Coagulation: random aggregation with denaturation and aggregation reactions where protein-protein interactions predominate over protein-solvent interactions and forms a coarse coagulum.