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Carboxylate salts
Carboxylate salts are less reactive than esters in nucleophilic acyl substitution reactions for two reasons. First, resonance stabilization of carboxylate salts is particularly significant because carboxylates have two identical, significant resonance structures;
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Nucleophilic aromatic substitution is possible, but involves substitution of a typical leaving group rather than a hydrogen atom. Remembering that S N 2 and S N 1 mechanisms are no
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Which of the following reduces the activation energy of a chemical reaction?
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