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What is the excitation threshold of a neuron? How does this threshold relate to the "all-or-nothing" rule of the neural transmission?
The excitation threshold of a neuron is the depolarization level that must be caused by a stimulus to be transmitted as a neural impulse. This value is about -50 mV.
The transmission of the neural impulse along the neuronal membrane obeys an all-or-nothing rule: or it happens with maximum intensity or nothing happens. Always and only when the excitation threshold is reached the depolarization continues and the membrane reaches its maximum possible positive polarization, about +35 mV. If the excitation threshold is not reached nothing happens.
The cystic fibrosis allele occurs in European populations with q=0.02, what fraction of this population can be expected to have cystic fibrosis?
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