What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Determinants of vascular tone, The vascular tone increases as the arterial ...

The vascular tone increases as the arterial size decreases. The tone at any time reflects the effects of excitory and inhibitory pathways. Neurotransmitters, physical forces like s

Explain the term- loss-of-function mutation, Where would a predicted silent...

Where would a predicted silent mutation have to be situated to actually result in a loss-of-function mutation (and potentially lead to the onset of disease)? A. Intron-exon jun

Viruses, Viruses Viruses are sub cellular, ultramicroscopic infectious...

Viruses Viruses are sub cellular, ultramicroscopic infectious agents of 20 nm-300 nm size range Many of them cause diseases like polio, dengue, small pox, measles, rabies, com

Anomalies related to oesophagus and stomach, Anomalies Related to Oesophagu...

Anomalies Related to Oesophagus and Stomach   Let us discuss briefly the anomalies of oesophagus and stomach. These are summarised as  follows: Associated Problems  1)  P

Biosynthesis of hemes and chlorophylls, In animals, some of bacteria and fu...

In animals, some of bacteria and fungi, and the first step in tetrapyrrole synthesis is the condensation of the amino acid glycine with succinyl  CoA (an intermediate  of the citri

Define briefly about the conjugated proteins, Define briefly about the Conj...

Define briefly about the Conjugated Proteins? Conjugated proteins are made up of simple proteins combined with a non- proteinous substance. The non-proteinous substance is know

Define gelatin - tests for presence of exoenzymatic activity, Explain Gelat...

Explain Gelatin - Tests for Presence of Exoenzymatic Activity? Gelatin is an incomplete protein as it lacks amino acid tryptophan. It is a major component of connective tissue

Define denaturation, Denaturation: With respect to the nucleic acids, refe...

Denaturation: With respect to the nucleic acids, refers to the conversion from the double-stranded to single-stranded state, many times achieved by heating or alkaline conditions.

Assessment - steps in nursing process, Assessment This includes the da...

Assessment This includes the data collection (nursing history and physical assessment), comparison of data with the normal, and analysis of the data gathered. Systematic an

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd