What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Tissue culture, Note on production of haploid by tissue culture.

Note on production of haploid by tissue culture.

What are rna polymerase subunits, Each of the three eukaryotic RNA polymera...

Each of the three eukaryotic RNA polymerases has more subunits or 12 and so these are big complex enzymes. The genes encoding some of the subunits of each  eukaryotic  enzyme  show

Explain about the absorbed moisture - water found in food, Explain about th...

Explain about the Absorbed Moisture - water found in food? It is the moisture that has passed through cell walls and entered the cytoplasm of the cell. It is this form of water

Biogeochemical cycle, The cyclic exchange of nutrient material between orga...

The cyclic exchange of nutrient material between organisms and non-living  environment is called biogeochemical  cycle ,'geo means earth: ''chemical' means chemical elements, thus

What is a skiers launch speed, In the aerials competition in skiing, the co...

In the aerials competition in skiing, the competitors speed down a ramp that slopes sharply upward at the end. The sharp upward slope launches them into the air, where they perform

Nervous system - brain, BRAI N (ENCEPHELON) Shape - Oval Positio...

BRAI N (ENCEPHELON) Shape - Oval Positio n - Situated in cranial cavity of skull. Medulla oblongeta comes out of foramen magnum in the form of spinal cord. Colou

Do all mammals have a placenta, Q. Do all mammals have a placenta? Mamm...

Q. Do all mammals have a placenta? Mammals of the monotreme group (platypus, echidnas) are oviparous egg- laying and they don't have a placenta. Mammals of the marsupial group

Etiologic factor of congestive cardiac failure, Q. Etiologic factor of Cong...

Q. Etiologic factor of Congestive Cardiac Failure? Congestive heart failure develops over a period of time when the necrotic tissues are not replaced by functional connective c

What is the basic structure of a virus, What is the basic structure of a vi...

What is the basic structure of a virus? Viruses are constituted of genetic material (DNA or RNA) covered by a protein capsule also called as a capsid. Some viruses, like HIV, h

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd