What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

What is dyspepsia, Q. What is Dyspepsia? Dyspepsia is the most frequent...

Q. What is Dyspepsia? Dyspepsia is the most frequent disorder which we all experience some time or the other. Dyspepsia is the term given to a group of gastrointestinal symptom

Describe about aorto pulmonary window, Describe about Aorto Pulmonary Windo...

Describe about Aorto Pulmonary Window ? This uncommon malformation consists of communication usually non-restrictive between the adjacent walls of the ascending aorta and pulmo

Define the recommended dietary allowance for thiamin (rda), Define the Reco...

Define the Recommended Dietary Allowance for Thiamin (RDA)? Thiamin, as it must be clear by now, is needed mainly for the metabolism of carbohydrate, branch-chained amino aci

What is the intracellular digestion, Q What is the intracellular digestion?...

Q What is the intracellular digestion? Cellular digestion or Intracellular digestion is the breaking in the interior of the cell of big molecules coming from outside or even fr

Angiosperms, why are the microspores in groups of four?

why are the microspores in groups of four?

Define about the sporocyst larva, Define about the Sporocyst Larva? Sp...

Define about the Sporocyst Larva? Sporocyst is the second larval stage in the life cycle of F. hepatica. It develops from the miracidium larva within the pulmonary chamber of

Evolutionary Biology-Genetic Drift, Imagine a population evolving by geneti...

Imagine a population evolving by genetic drift in which the frequency of allele K is 0.65. What is the probability that at some point in the future allele K will drift to a frequen

Peacock, exoskeleton of peacock

exoskeleton of peacock

Reproduction, Normal 0 false false false EN-IN X-NONE...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Define feeding for infants of hiv/aids mothers, Define Feeding for Infants ...

Define Feeding for Infants of HIV/AIDS Mothers? It is recommended to continue breast-feeding even if the disease will continue to be transmitted. If these infants are not breas

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd