Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Q. What is low - density lipoprotein receptor pathway?
Ans.
The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.
Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.
It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.
Homo sapiens first appeared in the fossil record between 200,000 to 300,000 years ago, The fossils were the Swanscomb man from England and Steinheim man from Germany. a) The Swa
Why do vestigial structures persist in modern organisms? Explain the evidence that indicates that species evolve over time. The environment will not select for or against
Define about the Sporocyst Larva? Sporocyst is the second larval stage in the life cycle of F. hepatica. It develops from the miracidium larva within the pulmonary chamber of
Explain the Digestion of carbohydrates? You are aware that 60-70% of energy is supplied by the dietary carbohydrates which are primarily present as polysaccharides (starch) fol
Long-term responses - Behaviour of Plants Plants alter their course of development to suit the prevailing environmental conditions. For example, leaf maturation and fall, onse
Define Vapor-pressure lowering and Osmotic pressure? 1. Vapor-pressure lowering: the decrease in the vapor pressure of a solution containing nonvolatile solutes, compared to th
Variety of Locomotion A number of animals are sendentary, remaining attached to some substratum. These animals may move parts of their body but this does not result in the mov
Amiodarone, quinidine, propafenone, and verapamil may increase digoxin levels up to 100 per cent. It is prudent to measure a blood level after 7-14 days (and at least 6 hours after
Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4
Define Mid root (latral) perforation? Perforation through latral wall of the root canal during cleaning and shaping or during post space preparation
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd