What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Which amino acid can form disulfide bonds, a. Which amino acid can form dis...

a. Which amino acid can form disulfide bonds? b. Which level of protein structure do disulfide bonds affect? How? c. Cytoplasmic proteins rarely form disulfide bonds, even if they

Dissolved gases and alkalinity, Dissolved Gases and Alkalinity Disso...

Dissolved Gases and Alkalinity Dissolved Gases The marine environment serves as a gigantic reservoir of dissolved oxygen and carbon dioxide, which respectively help reg

Explain how a water molecule is produced, Explain how a water molecule is p...

Explain how a water molecule is produced when glucose and fructose undergo a condensation reaction. The glucose molecule releases a hydroxide ion, OH -, and the fructose molec

Define measuring direct aerobic fitness, Define Measuring Direct Aerobic Fi...

Define Measuring Direct Aerobic Fitness (VO 2 max) For direct measurement of VO, max, the subject is asked to perform exercise for 12 to 15 minutes. A stationary bicycle or a

What might explain the pattern, A group of Ethiopians were assayed for CCR5...

A group of Ethiopians were assayed for CCR5-del32 deletion polymorphism. 223 were +/+, 64 were +/del32, and 6 were del32/del32. Are the observed data significantly different from H

Explain catastrophism, Catastrophism Once-popular belief which events in t...

Catastrophism Once-popular belief which events in the history of earth had occurred in the past a sudden events and by processes different from those operating today. The periods

DNA replication, What is cDNA and what is its function and mechanism of act...

What is cDNA and what is its function and mechanism of action?

Systolic versus diastolic failure, Systolic heart failure is a classic hear...

Systolic heart failure is a classic heart failure where the inotropic (contractile) state is impaired and the expulsion of blood is not adequate. So the main manifestations of syst

What is the type of genetic inheritance of daltonism, What is the type of g...

What is the type of genetic inheritance of daltonism? Is daltonism more frequent in men or in women? What is the physiological explanation for the daltonism? Daltonism is a re

Importance of the glucose blood level for human health, Q. What is the impo...

Q. What is the importance of the glucose blood level for human health? The glucose blood level (glycemia) must be kept normal if it is abnormally low there is not sufficient gl

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd