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Q. What is low - density lipoprotein receptor pathway?
Ans.
The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.
Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.
It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.
These mycotoxins are structurally and biologically related to the aflatoxins, and like the latter, they cause hepatocarcinogenic activity in animals. Among the organisms that prod
Ciliates - Parasitic Protozoan The only ciliate of medical and veterinary importance is Balantidium coli which inhabit the large intestine of man, apes, monkeys and pigs. B. c
What is photoperiodism? Photoperiodism is the biological response shown by some living beings to their daily time of light exposure (photoperiod).
are protozoans primitive to life .
Single-cell organisms, protists, have always been a problem for taxonomists who have trouble describing categories for organisms. Their mixed feeding habits that include being capa
Do all genetic diseases result from alteration in the number of chromosomes of the cells? Besides aneuploidies there are other genetic diseases, other chromosomal abnormalities
Myocardial contractility is mostly dependent on the level of sympathetic nerve activity and is also increased by circulating catecholamines and inotropic drugs like dopamine and do
What are the stomata? How these structures participate in the plant transpiration? The Stomata (singular, stoma) are small specialized passages for gases and water present in t
Q. Explain about Dry heat sterilization? It is used to sterilize glass ware, forceps, scissors, scalpels, all glass syringes, swabs, some pharmaceuticals products such as liqui
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