What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Predisposing factors and pathphysiology of meningitis, Predisposing Factors...

Predisposing Factors The patients with diabets mellitus, malignancies and those on immunosuppressive drugs have reduced resistance and are more susceptible to develop meningi

What are the risks of migration, What are the Risks of migration Eg ...

What are the Risks of migration Eg Getting lost (blown off course or similar) and the effect of this when there is a limited fuel supply. Insufficient food to build

Determine the testing for albumin in urine, Determine the Testing for Album...

Determine the Testing for Albumin in Urine Acetic Acid Test About 2 - 8 mgm/dl of protein is excreted in urine which is not usually detected by routine test. The testing o

Choline, CHOLINE Found in egg liver & kidney. Synthesized in body...

CHOLINE Found in egg liver & kidney. Synthesized in body with acetyle coA. It forms acetylcholine. Deficiency causes damage to kidney.

Maturation promoting factor, • Cyclins accumulate during the G1, S, and G2 ...

• Cyclins accumulate during the G1, S, and G2 phases of the cell cycle. • By the G2 checkpoint (the red bar in the figure), enough Cyclin is available to form MPF complexes (aggre

Explain restricted fragment polymorphism, Q. Explain Restricted fragment po...

Q. Explain Restricted fragment polymorphism? This method makes use of a group of enzymes termed restriction enzymes which recognise particular sequence of DNA and act as "molec

Renal glycosuria and self monitoring of blood glucose, Renal Glycosuria ...

Renal Glycosuria Renal glycosuria is a condition in which the glucose is excreted in the urine in spite of normal blood sugar levels. Self Monitoring of Blood Glucose (SMBG

What is forebrain, Q. What is Forebrain? Forebrain: Found in the area o...

Q. What is Forebrain? Forebrain: Found in the area of the forehead, this part of the brain is concerned with all the emotions, planning, organising, reasoning, memory, movement

Conjugated proteins, CONJUG A TE D PROTEINS Besides being made of po...

CONJUG A TE D PROTEINS Besides being made of polypeptides, the conjugated proteins posses additional groups, metals or ions. Consists of protein and non-protein parts.

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd