What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Causes of extinction, CAUSES OF EXTINCTION - 1 .       HUNTING - ...

CAUSES OF EXTINCTION - 1 .       HUNTING - Man started hunting wild animlas for food and safety trade and fun. It may be subsistence hunting, commercial hunting and sp

Explain the absorption of itraconazole capsules, Explain The absorption of ...

Explain The absorption of itraconazole capsules It is decreased with concurrent use of drugs that reduce gastric acidity, such as antacids, H2-receptor blockers, proton pump in

What is the endosymbiotic hypothesis, Q. What is the endosymbiotic hypothes...

Q. What is the endosymbiotic hypothesis about the origin of mitochondria? And what are the molecular facts that support the hypothesis? And To which other cellular organelles can t

What is oxidized starch and starch acetates, Oxidized starch Coating an...

Oxidized starch Coating and sealing  agent, emulsifier, dough conditioner for bread, binding agent as gum Arabic replacer, lemon curd manufacture, salad cream, mayonnaise.

Symptoms of constipation, Q. show the Symptoms of constipation? Have yo...

Q. show the Symptoms of constipation? Have you ever suffered from constipation? Do you recall the symptoms associated with the problem? Yes, the symptoms were specific to havin

Define energy requirements and dietary energy recommendation, Define Energy...

Define Energy Requirements and Dietary Energy Recommendations? Energy requirement, as you may recall studying earlier, is the amount of food energy needed to balance energy exp

Induction of hydrolases - responses to infection, Induction of hydrolases -...

Induction of hydrolases - Responses to Infection Plants do respond to attack by pathogens. To restrict their spread the cells synthesise and secrete enzymes to hydrolyse the c

Determine the production of red blood cells, What is the substance that sti...

What is the substance that stimulates the production of red blood cells? Which is the organ that secretes it? Under what conditions does this secretion increase? The substance

Lung abscess, Lung Abscess: Lung  abscess  is a localised collection o...

Lung Abscess: Lung  abscess  is a localised collection of pus in  the pulmonary parenchyma as a result of  suppuration and necrosis. The obstruction  of the bronchus of the in

What is the connection between tissue fluid and plasma, What is the connect...

What is the connection between tissue fluid, plasma and lymph? Tissue fluid is plasma (minus its proteins) which has leaked out of the capillaries. Lymph is tissue fluid which

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd