What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Private or voluntary health insurance schemes, Normal 0 false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Pond sucession, make a assignment of pond succesion

make a assignment of pond succesion

Define alanine cycle, Alanine cycle Alanine Cycle  :  In the alanine ...

Alanine cycle Alanine Cycle  :  In the alanine cycle the pyruvate formed from glycolysis  in  the muscle is converted  to alanine by transamination  reaction. Alanine is rele

Explain operational taxonomic units - numerical taxonomy, Explain Operation...

Explain Operational Taxonomic Units - Numerical Taxonomy 1) Then the characters to be used for studying the OTUs are selected. Usually a large number of characters are taken as

Recognize the eight stages of meiosis, Can you recognize the eight stages o...

Can you recognize the eight stages of meiosis based on the location and behavior of the chromosomes? Drag the diagrams of the stages of meiosis onto the targets so that the four st

Explain the systemic antibiotic cover, Explain the systemic antibiotic cove...

Explain the systemic antibiotic cover The need for  systemic antibiotic cover should be considered. The original protocols recommended an antibiotic such as amoxicillin 250 mg

Will argon tend to form bonds with other elements, The atomic number of arg...

The atomic number of argon is 18. Will argon tend to form bonds with other elements? Describe your answer. Argon will not tend to form bonds with other elements. With an atomi

What is the salivary digestive enzyme, Q. What is the salivary digestive en...

Q. What is the salivary digestive enzyme? Which type of food does it digest and into which smaller molecules does it transform the food? The salivary hydrolase is known as sali

What is lasting form in gametophyte-pteridophytes-sporophyte, What is the l...

What is the lasting form in the gametophyte, pteridophytes or the sporophyte? How can it be compared to bryophytes? The lasting form in pteridophytes is the diploid (2n) sporop

Parasitology, how trematodes/nematodes adapt to their parasitic mode of fee...

how trematodes/nematodes adapt to their parasitic mode of feeding

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd