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Q. What is low - density lipoprotein receptor pathway?
Ans.
The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.
Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.
It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.
Prophylaxis High-risk neutropenic patients, such as those undergoing allogeneic and certain autologous stem cell transplants, and those with hematologic malignancy who are exp
Division of the exconjugant into daughter paramoecia: Each exconjugant, with a single micronucleus and four macronuclei divides twice and forms four daughter paramoecia. E
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Of the following, which mechanisms are significant in the death of erythrocytes (pron: eh-rith-reh-sites) in human blood? Is it a) Phagocytosis (pron: fag-eh-seh-toe-sis) b)
Would you expect the muscle fibers of the tongue to be striated or smooth? What about the muscle of the diaphragm/ Explain your answer.
Explain Common Concerns during Pregnancy? Many of the physiological changes that occur during pregnancy affect the digestive tract and may cause discomfort to the mother. Most
Food chain is the simplest representation of energy flow in the community. At the base is energy stored in the plants, which are eaten by the small organisms, which in turn are ea
Implant success 1) An individual, unattached implant is immobile when tested clinically. 2) A radiograph that does not demonstrate any evidence of perimplant radiolucency.
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