What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Assessment of infective endocarditis, Assessment   Infective endocardit...

Assessment   Infective endocarditis  is characterised  by insidious onset of fever, malaise, night- sweats and weight loss. Other signs include vomiting, fatigue, headache, mya

Nervous system - spinal cord, SPINAL CORD (MYELON) It is part of CNS. 4...

SPINAL CORD (MYELON) It is part of CNS. 45 cm long (in woman 43 cm) & weight 35 gms. Origi n from lower part of medulla oblongeta. Shape - Long cylindrical,

Adolescence, ADOLESCENC E  - It is the period of growth from the onset ...

ADOLESCENC E  - It is the period of growth from the onset of puberty to the completion of growth & maturity. It extends between 12- 20 yrs. It is a period of rapid physical

Define factors affect the rate and total drying time, Define factors affect...

Define factors affect the rate and total drying time? Four main factors affect the rate and total drying time, which include: a) The properties of the products (the moisture

Leishmanias – flagellates, Leishmanias – Flagellates Species of the ge...

Leishmanias – Flagellates Species of the genus Leishmania are parasites of mammals including man. Leishmanias infections occur over wide regions of the world from Asia, the ne

Define institutional and cultural barriers - infuse biology, Define Institu...

Define Institutional and Cultural Barriers - Infuse Biology? Inside the university, the departmental promotion and tenure committees understand well the value of contribution t

Vaso-constriction, what is a vaso-constriction? what are the effects of vas...

what is a vaso-constriction? what are the effects of vaso-constriction in the skin?

Aquatic biomes, If you look up a world atlas you would notice that most of ...

If you look up a world atlas you would notice that most of the earth's surface is covered by the waters of the oceans (about 71%). Beneath the water surface is a fascinating world

Explain the procedure of taking blood pressure, Explain the Procedure of Ta...

Explain the Procedure of Taking Blood Pressure - Explain the procedure to the patient. In case patient is coming for first time to check the blood pressure explain to the patie

What is working memory, Q. What is Working Memory? Working Memory: It h...

Q. What is Working Memory? Working Memory: It has often been suggested that memory does not always work in three stage sequence and the model of memory system comprising of sen

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd