What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Traumatic reticuloperitonitis (trp), Tr aumatic reticuloperitonitis (TRP) ...

Tr aumatic reticuloperitonitis (TRP) It is also known as traumatic gastritis, hardware disease or traumatic reticulitis. Et i o l o g y : Frequentl

Definition of probiotics and prebzotics, Definition of probiotics and prebz...

Definition of probiotics and prebzotics? An early definition of probiotics is 'organisms and substances which contribute to intestinal microbial balance'. Later the word 'subst

Explain the staphylococcus - characteristics of bacteria, Explain the Staph...

Explain the Staphylococcus - Characteristics of Bacteria? Staphylococcus - It is gram positive, nonsporulating facultative anaerobic cocci present in grape-like clusters. These

Zoonoses disease-tuberculosis, Tuberculosis Tuberculosis is a specific ...

Tuberculosis Tuberculosis is a specific communicable disease involving the pulmonary and extra- pulmonary tissues and is characterized by chronic clinical manifestations. The i

What is osseointegration, What is Osseointegration Osseointegration was...

What is Osseointegration Osseointegration was the hallmark of success in implant dentistry in the 1980s. It was believed that an implant was successfully integrated when there

Explain non-starch polysaccharides, NON-STARCH POLYSACCHARIDES A polysa...

NON-STARCH POLYSACCHARIDES A polysaccharide often termed as complex carbohydrate. Besides starch, a mixture of substances called non starch polysaccharide (NSP), also constitut

Cell membrane, CELL MEMBRANE It is biological, thin, elastic, flexib...

CELL MEMBRANE It is biological, thin, elastic, flexible & selective permeable membrane. Term "Cell membrane" was coined by Negeli & Crammer 1855. Term " Plasma membr

Illustrate about mylohyoid muscle, Mylohyoid muscle Surgical manipulati...

Mylohyoid muscle Surgical manipulation at the crest of a severely resorbed ridge may injure the mylohyoid muscle. Manipulation of the tissues of the floor of the mouth for plac

The blood go after leaving the left atrium, To which heart chamber does the...

To which heart chamber does the blood go after leaving the left atrium? What is the valve that separates these compartments? The arterial blood that has come from the lungs to

Define protein requirement during tuberculosis, Define Protein requirement ...

Define Protein requirement during tuberculosis Protein : Achronic infection  is marked by a prolonged duration of fever. This leads to wasting of muscles, increased nitrogen

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd