What is low - density lipoprotein receptor pathway, Biology

Assignment Help:

Q. What is low - density lipoprotein receptor pathway?

Ans.

The increasing cellular free cholesterol generated regulates the activities of two enzymes that are of crucial importance in cholesterol homeostasis. HMG-CoA reductase (the major rate-determining enzyme in the cholesterol synthetic pathway) is inhibited, reducing cholesterol synthesis. Acyl CoA: cholesterol acyl transferase (ACAT) is activated, thus facilitating the re-esterification of cholesterol to cholesterol ester.

Thus the LDL receptor pathway is a closely integrated system by which cells acquire cholesterol and cellular cholesterol homeostasis is maintained. The therapeutic potential of interrupting this pathway will become apparent when the statin drugs which are inhibitors of HMG-CoA reductase are discussed.

It is the activity of LDL receptors in the liver that largely controls plasma LDL levels. Approximately 70 per cent of LDL is removed by this pathway.


Related Discussions:- What is low - density lipoprotein receptor pathway

Constrictive pericarditis-pericardial diseases, Constrictive Pericarditis :...

Constrictive Pericarditis :  It is usually the end stage of inflammatory process involving pericardium. In developing world, infection with mycobacterium tuberculosis is still com

Indicator organism, a) What are the needsfor an organism to be an indicator...

a) What are the needsfor an organism to be an indicator organism? b)  In Australia, National Parks and coastal beaches attract various visitors during holiday periods.  EPA is

Principle of colorimetric method-2, Define Principle of colorimetric method...

Define Principle of colorimetric method-2, 4 dinitrophenylhydrazine? Ascorbic acid is oxidized to dehydro ascorbic acid by copper (Cu ++ ) ions. 2, 4 dinitrophenyl hydrazine re

Briefly explain about gelation, Explain Gelation Gelation, which occurs...

Explain Gelation Gelation, which occurs when yolk is frozen and thawed, is apparently due to the aggregation of yolk lipoproteins because  of the imbalance and shift in water.

Explain herbals of brunfels, Explain Herbals of Brunfels? Between the y...

Explain Herbals of Brunfels? Between the years 1530 and 1536 Otto Brunfelsius (Brunfels) (1463-1534) published his 'Herbal' which consisted of descriptions of a large number of

How nutritional status affects the bmr, How Nutritional status affects the ...

How Nutritional status affects the BMR? Under nutrition and starvation are the factors which require consideration. Prolonged under nutrition or starvation causes a reduction o

Explain the coenzyme in enzyme catalyzed reactions, Explain the Coenzyme in...

Explain the Coenzyme in enzyme catalyzed reactions? Thiamin functions as the coenzyme thiamin pyrophosphate (TPP) in the inetabolism of carbohydrates and branched- chain amino

Functions of testis, Functions of Testis The testis performs the follo...

Functions of Testis The testis performs the following two functions: Proliferation of spermatozoa and Secretion of steroid hormones

Sex-limited traits, can u show the different activities on the topic

can u show the different activities on the topic

Ecological pyramids - ecosystem, Ecological Pyramids - Ecosystem The a...

Ecological Pyramids - Ecosystem The ancient Egyptians constructed elaborate tombs called pyramids. The base of the pyramid is broad and it supports the upper levels of the str

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd