What is dyslipidaemia, Biology

Assignment Help:

What is Dyslipidaemia ?

The results of epidemiological studies, as well as trials with angiographic or clinical endpoints, confirm the importance of various lipid fractions in the pathogenesis of atherosclerosis. There is a strong and graded positive association between total and LDL cholesterol and risk of vascular events (mainly ischaemic heart disease) extending over a wide range of cholesterol concentrations. This association applies to individuals with or without established CAD as well as to women and men. Other risk factors can substantially aggravate the effects of LDL cholesterol.

The other fraction of the lipid is HDL cholesterol. It is also called 'good' cholesterol as there is a strong and inverse association between HDL cholesterol and the risk of CAD in both men and women and in subjects with or without established CAD; the lower the concentration of HDL-cholesterol the greater the risk of CAD. The inverse association between HDL-cholesterol levels and CAD risk at least equals the positive association between CAD risk and serum LDL cholesterol events. There is now evidence from the Veterans Administration High density Lipoprotein Cholesterol Intervention Study (VA-HIT) that the increase in HDL-cholesterol in CAD patients is followed by a significant decrease in major coronary events.

Triglycerides are the other lipid components in the blood 2nd they also contribute to an increased risk of coronary artery disease by a number of mechanisms. The triglyceride rich lipoproteins may be independently atherogenic or they may promote atherosclerosis by inducing a procoagulant state and promoting thrombosis.

While level of individual lipid factor may be important in the pathogenesis of coronary atheroclerosis, interplay of different lipid fractions is much more significant. For example, at a given level of LDL cholesterol, the atherogenic potential is enhanced in presence of low HDL cholesterol level. Again, the ratio of total cholesterol (TC) to HDL cholesterol (HDLc) emerges as the most powerful predictor of atherosclerosis; a TC/HDLc ratio more than 4,5 is associated with high risk of CAD.

 


Related Discussions:- What is dyslipidaemia

Which type of defense cell do bacteria attract, Which type of defense cell ...

Which type of defense cell do bacteria attract and cause to multiply during the inflammation process? What is the name given to the waste material produced by the inflammation trig

How did the industrial revolution in england, How did the industrial revolu...

How did the industrial revolution in England offer an example of natural selection? One of the classic instances of natural selection is regarding the moths of industrial zones

Define the bioavailability of vitamins, Define the Bioavailability of Vitam...

Define the Bioavailability of Vitamins? The term bio availability refers to the overall efficiency of utilization, including physiological and biochemical processes involved in

Why is meiosis important for the maintenance, Why is meiosis important for ...

Why is meiosis important for the maintenance of the normal quantity of chromosomes of a species with sexual reproduction? A reduction to a half of the maximum normal quantity o

What are the digestive functions of the liver, What are the digestive funct...

What are the digestive functions of the liver? Besides making bile for release in the duodenum, the liver has other digestive functions. The venous network that absorbs nutr

Auxins - plant growth substances, Auxins - Plant Growth Substances Jul...

Auxins - Plant Growth Substances Julius Sachs (1882) first suggested on the basis of his observations that there are special substances for forming roots and some special subs

Relate fibro-osseous retention and osseointegration, Fibro-osseous Retenti...

Fibro-osseous Retention V/S Osseointegration Fibro-osseous retention is the tissue to implant contact interposition of the healthy, dense collagenous tissue between the implant

Define gas liquid chromatography, Define Gas liquid chromatography? Thi...

Define Gas liquid chromatography? This is used for separating and identifying volatile compounds of fatty acids, hydrocarbons, sterols, amino acids and lipids, even from nanogr

Zinc (zn) - micronutrients, Zinc (Zn) - Micronutrients In its function...

Zinc (Zn) - Micronutrients In its function in some enzyme systems, zn 2+ resembles Mn 2+ in that it brings about substrate binding and conformational changes in enzymes. A n

Describe the positive end expiratory pressure, Describe the Positive End Ex...

Describe the Positive End Expiratory Pressure (PEEP)? A positive pressure may be applied at the end of the expiratory phase during mechanical ventilation, instead of allowing t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd