What is dyslipidaemia, Biology

Assignment Help:

What is Dyslipidaemia ?

The results of epidemiological studies, as well as trials with angiographic or clinical endpoints, confirm the importance of various lipid fractions in the pathogenesis of atherosclerosis. There is a strong and graded positive association between total and LDL cholesterol and risk of vascular events (mainly ischaemic heart disease) extending over a wide range of cholesterol concentrations. This association applies to individuals with or without established CAD as well as to women and men. Other risk factors can substantially aggravate the effects of LDL cholesterol.

The other fraction of the lipid is HDL cholesterol. It is also called 'good' cholesterol as there is a strong and inverse association between HDL cholesterol and the risk of CAD in both men and women and in subjects with or without established CAD; the lower the concentration of HDL-cholesterol the greater the risk of CAD. The inverse association between HDL-cholesterol levels and CAD risk at least equals the positive association between CAD risk and serum LDL cholesterol events. There is now evidence from the Veterans Administration High density Lipoprotein Cholesterol Intervention Study (VA-HIT) that the increase in HDL-cholesterol in CAD patients is followed by a significant decrease in major coronary events.

Triglycerides are the other lipid components in the blood 2nd they also contribute to an increased risk of coronary artery disease by a number of mechanisms. The triglyceride rich lipoproteins may be independently atherogenic or they may promote atherosclerosis by inducing a procoagulant state and promoting thrombosis.

While level of individual lipid factor may be important in the pathogenesis of coronary atheroclerosis, interplay of different lipid fractions is much more significant. For example, at a given level of LDL cholesterol, the atherogenic potential is enhanced in presence of low HDL cholesterol level. Again, the ratio of total cholesterol (TC) to HDL cholesterol (HDLc) emerges as the most powerful predictor of atherosclerosis; a TC/HDLc ratio more than 4,5 is associated with high risk of CAD.

 


Related Discussions:- What is dyslipidaemia

Define the meaning of isomerism, Define the Meaning of Isomerism? All m...

Define the Meaning of Isomerism? All monosaccharides exhibit isomerism. An asymmetric carbon or chiral carbon contains four different groups attached to it. The formula 2 n de

Difference between cryptogamic and phanerogamic plants, What is the differe...

What is the difference among cryptogamic and phanerogamic plants? Cryptogamic (hidden sex organs) plants are those that do not show flowers or seeds. They comprise the bryophy

Which part of heart serves as an effector, Which of the following serves as...

Which of the following serves as an effector, or as part of an effector, that functions in a negative feedback system? A. Nicotinic Acetylcholine Receptors (nAChR) in SA node c

Essay, “Define nosocomial infections. Discuss the factors that might influe...

“Define nosocomial infections. Discuss the factors that might influence whether a patient may acquire nosocomial infection. How might these risks be reduced?”

Define standardization - nutritional biochemistry, Define Standardization ...

Define Standardization - Nutritional  Biochemistry? One of the substances involved in a titration must be used as a standard for which the amount of substance present is accura

Differance between descending thoracic or abdominal aneurysm, Differance be...

Differance between Descending Thoracic or Abdominal Aneurysm ? Descending Thoracic Aortic and Thoraco-Abdominal Aneurysm :  The approach is through n left postero-lat

Principles of numerical taxonomy, Q. Principles of Numerical Taxonomy? ...

Q. Principles of Numerical Taxonomy? Numerical taxonomy is based on the following 7 principles. 1) The greater the content of information in the taxa of a classification is an

Types of stem cells-pulp tissue revascularization, Embryonic stem cells: c...

Embryonic stem cells: can differentiate into all cell types of the specialized embryonic tissues when given sufficient and necessary stimulation for a specific cell type, e.g. Plu

Emerging trends in nutritional content of technologically, Define Emerging ...

Define Emerging trends in the nutritional content of technologically? Increased concern about the nutritional content of technologically derived, advanced foods is expressed by

Sastry, he heartbeat begins with the depolarization of the

he heartbeat begins with the depolarization of the

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd