What is dyslipidaemia, Biology

Assignment Help:

What is Dyslipidaemia ?

The results of epidemiological studies, as well as trials with angiographic or clinical endpoints, confirm the importance of various lipid fractions in the pathogenesis of atherosclerosis. There is a strong and graded positive association between total and LDL cholesterol and risk of vascular events (mainly ischaemic heart disease) extending over a wide range of cholesterol concentrations. This association applies to individuals with or without established CAD as well as to women and men. Other risk factors can substantially aggravate the effects of LDL cholesterol.

The other fraction of the lipid is HDL cholesterol. It is also called 'good' cholesterol as there is a strong and inverse association between HDL cholesterol and the risk of CAD in both men and women and in subjects with or without established CAD; the lower the concentration of HDL-cholesterol the greater the risk of CAD. The inverse association between HDL-cholesterol levels and CAD risk at least equals the positive association between CAD risk and serum LDL cholesterol events. There is now evidence from the Veterans Administration High density Lipoprotein Cholesterol Intervention Study (VA-HIT) that the increase in HDL-cholesterol in CAD patients is followed by a significant decrease in major coronary events.

Triglycerides are the other lipid components in the blood 2nd they also contribute to an increased risk of coronary artery disease by a number of mechanisms. The triglyceride rich lipoproteins may be independently atherogenic or they may promote atherosclerosis by inducing a procoagulant state and promoting thrombosis.

While level of individual lipid factor may be important in the pathogenesis of coronary atheroclerosis, interplay of different lipid fractions is much more significant. For example, at a given level of LDL cholesterol, the atherogenic potential is enhanced in presence of low HDL cholesterol level. Again, the ratio of total cholesterol (TC) to HDL cholesterol (HDLc) emerges as the most powerful predictor of atherosclerosis; a TC/HDLc ratio more than 4,5 is associated with high risk of CAD.

 


Related Discussions:- What is dyslipidaemia

Define feeding and nutritional management of dysphilgia, Define Feeding and...

Define Feeding and Nutritional Management of Dysphilgia? A multidisciplinary approach is essential for successful management of dysphilgia. Patient, nurse, physician, die titi

Dietary management for ulcerative colitis, Q. Dietary Management for ulcera...

Q. Dietary Management for ulcerative colitis? Proper dietary management is important for maintaining a good nutritional status of the patient. Long-term management is generally

Show characteristics of protozoans, Q. What are the characteristics of prot...

Q. What are the characteristics of protozoans that make them resemble animals? Protozoans are unicellular beings with some related characteristics to animal cells. In compar

Explain the types of cell reproduction, Explain the Types of cell Reproduct...

Explain the Types of cell Reproduction ? One of the major characteristics of living organisms is their ability to grow and reproduce. This is accomplished by cell division. In

An experiment to test the hypothesis, How would you design, in principle, a...

How would you design, in principle, an experiment to test the hypothesis that a certain variety of lettuce seed needed daylight in order to germinate?  You would need as large

What is parkinsons disease, Q. What is Parkinson's disease? The Parkins...

Q. What is Parkinson's disease? The Parkinson's disease is a degenerative disease of the nervous system in which the major manifestations are progressive motor disturbances, li

How to investigate mitral stenosis by electrocardiogram, Q. How to Investig...

Q. How to Investigate mitral stenosis by Electrocardiogram? Electrocardiographic changes are not specific for mitral stenosis and are never diagnostic for any valvular heart di

Enzymes in clinical diagnosis, ENZYMES IN CLINICAL DIAGNOSIS The ration...

ENZYMES IN CLINICAL DIAGNOSIS The rationale for measuring plasma or serum enzyme levels is based on the premise that these  levels reflect changes  that  have  occurred  in  a

Pathophysiology of chronic wasting disease, Q. Pathophysiology of Chronic w...

Q. Pathophysiology of Chronic wasting disease? We all know that heart attack i.e. myocardial infarction is not the beginning but a last stage representing acute clinical manife

Explain about the brownian ratchets and molecular motors, Explain about the...

Explain about the Brownian ratchets and molecular motors ? How work is carried out by molecules within biological cells is essential to understanding how cells function. A clue

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd