What happens to denatured enzyme regarding it functionality, Biology

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What happens to a denatured enzyme regarding its functionality? How can that result be explained with the help of the lock and key model?

According to the lock and key model the enzyme functionality depends totally on the integrity of the activation center, a molecular region with exact spatial characteristics. After the denaturation the spatial conformation of the protein is modified, the start center is destroyed and the enzyme loses its catalytic activity.

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