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There is high level of fluctuation in a zigzag pattern in the time series for RESI1 which indicates that there is possibly negative autocorrelation present.
Column C11 shows the variation of the values that are illustrated in the time series graph and in this case there is possibly negative autocorrelation but it is not clearly visible on the time series therefore it can be identified from the RESI1 figures below as it is positive value at first and then drops down to a negative value.
In a time series an outlier is referred to a point that is usually a high data point or small data point in contrast to the rest of the data. There is a definite outlier in this times series which is value 0.203811 with the index of 448 because most data points fall in between 0.00 to 0.05 as evident on the time series. This data point has high leverage as they disproportionate distance away from the rest of values and it can have an influence on the slope of the regression line. A zigzag pattern or a wave form cannot be easily recognized and shows there is no autocorrelation.
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The Null Hypothesis - H0: There is no heteroscedasticity i.e. β 1 = 0 The Alternative Hypothesis - H1: There is heteroscedasticity i.e. β 1 0 Reject H0 if |t | > t = 1.96
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Continual reassessment method: An approach which applies Bayesian inference for determining the maximum tolerated dose in a phase I trial. The method starts by assuming a logistic
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