Regulation of Glycogen Metabolism

It  is  important  for  you  to  understand  that  glycogenesis and gluconeogenesis are regulated  reciprocally. There  is  a  hormonal  regulation  system  functioning at the muscle and  liver level, which  regulates the glycogen metabolism. We  have studied about  the phosphorylation cascade involving the hormones epinephrine and glucagon above.  Epinephrine  promotes glycogenolysis  and inhibits glycogenesis.  It stimulates the formation of cAMP by activating adenylate cyclase in the muscle. Insulin, another hormone,  increases glycogenesis  and  decreases glycogenolysis  in  the muscle.  It heightens the entry of glucose unit  in  the muscle cells. It reduces cAMP levels by speeding up  the destruction of  cAMP  by  phosphodiesterase.