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Prognostic scoring system is a technique of combining the prognostic information contained in the number of threat factors, in a manner which best predicts each patient's risk of the disease. In number of cases a linear combination of the scores is used with the weights being derived from, for instance, a logistic regression. An instance of such a system developed in the British Regional Heart Study for predicting and analysing the men aged 40-59 years to be at risk of ischaemic heart disease over next ?ve years is given as follows:
Minimization is the method or technique for allocating patients to the treatments in clinical trials which is usually the acceptable alternative to random allocation. The procedur
The Null Hypothesis - H0: β 1 = 0 i.e. there is homoscedasticity errors and no heteroscedasticity exists The Alternative Hypothesis - H1: β 1 ≠ 0 i.e. there is no homoscedasti
Clustered data : The term applied to both the data in which the sampling units are grouped into the clusters sharing some common feature, for instance families or geographical reg
we are testing : Ho: µ=40 versus Ha: µ>40 (a= 0.01) Suppose that the test statistic is z0=2.75 based on a sample size of n=25. Assume that data are normal with mean mu and standa
Continual reassessment method: An approach which applies Bayesian inference for determining the maximum tolerated dose in a phase I trial. The method starts by assuming a logistic
Outliers - Reasons for Screening Data Outliers are due to data entry errors, subject is not a member of the population that the sample is trying to represent, or the subject i
Bonferroni correction : A procedure for guarding against the rise in the probability of a type I error when performing the multiple signi?cance tests. To maintain probability of a
You have learned that there are 3 major central measures of any data set. Namely: mean, median, and mode. Which of the three, do the outliers affect the most?
Chernoff's faces : A method or technique for representing the multivariate data graphically. Each observation is represented by the computer-created face, the features of which are
The number of employees absent from work at a large electronics manufacturing plant over aperiod of 106 days is given in the table below. 146 141 139 140 145 141 142 131 142 140
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