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PHYSICAL STATE OF PROTOPLASM
Several theories have been given about its physical structure -
(i) Granular Theory (Proposed by Altman, Hanstein, 1886) - Granules embedded in a fluid, those are known as bioplast/cytoplast. Henle & Megi used the word plastidules for granules
(ii) Reticular Theory (Proposed by Fromman, Klein, Carnoy, 1885) - Reticulum of fibres embedded in a fluid.
(iii) Fibrillar Theory (Proposed by Velton & Flemming, 1882) - Fibrils dispersed in a liquid.
(iv) Alveolar Theory (Proposed by Butschli 1878) - Droplets or alveoli is present in it.
(v) Crystallo-Colloidal Theory (Proposed by Fischer, Hardy Wilson 1894) - Substances dissolved and dispersed in water forming both true solution as well as colloidal solution.
Combination of diuretics may be indicated in patients previously resistant to furosemide alone. Profound diuresis and clinical improvement may occur after the addition of metolazon
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