Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

Review of literature - steps of research process, Determine the purpose of ...

Determine the purpose of  the study: There must be  a sound  rationale  or justification for every research project.  If  the pui-pose of  the  study is clearly presented and just

Cow-pox (vaccinia), C o w - po x (vaccinia) E p ide...

C o w - po x (vaccinia) E p idemiology: This infection, although mostly occurring in cows, sometimes also occurs in buffaloes. Under natural conditions, t

Describe about congenital cardiac conditions encountered, Describe about Co...

Describe about Congenital Cardiac Conditions Encountered in Adults ? The entire population of adults with CHD is constituted by patients whose cardiac malformations have a natu

Explain tetanus and diphtheria, Tetanus and Diphtheria  Everyone who ha...

Tetanus and Diphtheria  Everyone who has had a primary series as a child should receive a tetanus-diphtheria toxoid (Td) booster injection once every 10 years. Before traveling

Modes of nitrate reductase and nitrite reductase, Modes of NO - 3 reducti...

Modes of NO - 3 reduction Accordingly, there are the following three basic modes of NO - 3 reduction. Directly dependent upon photosynthesis as in cyanobacter

Principal categories in classification, Q. Principal categories in classifi...

Q. Principal categories in classification? First of all there is a need to know what classification is? Let us define in simple term. Classification is placing of a plant (or g

Signal for ribosome to begin translating the transcript, Which of the follo...

Which of the following serves as a signal for the ribosome to begin translating the transcript? A. Addition of the poly a tail to the 3' end of the transcript B. Deamination

Define heart diseases - excessive fat intake, Define Heart Diseases - exces...

Define Heart Diseases - excessive fat intake? Heart diseases show strong links to fat and cholesterol intake. Foods rich in cholesterol are of animal origin and given in Table.

Primary consideration in risk management decisions, Protection of  human...

Protection of  human  health should  be  the primary consideration  in risk  management  decisions. Decisions on acceptable levels of risk should be determined primarily by hum

Intermediate filaments - role of cytoskeleton structures, Intermediate fila...

Intermediate filaments - Role of Cytoskeleton Structures These filaments are intermediate in size among microtubules and microfilaments and are 10 nm in diameter. Five classes

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd