Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

Functions of mitochondria, FUNCTION S OF MITOCHONDRIA Cell Oxidation ...

FUNCTION S OF MITOCHONDRIA Cell Oxidation - Mitochondria plays an important role in ATP synthesis during aerobic respiration. Mitochondria are known as Power house of cell b

What are the factors responsible for corneal hydration, What are the factor...

What are the factors responsible for corneal hydration? The factors responsible for corneal hydration are as follows: i. Stromal swelling pressure ii. Barrier function of

Human embryo, Human embryo: After fertilization the human embryo divide...

Human embryo: After fertilization the human embryo divides mitotically and develops two membranes: 1) Chorion 2) Amnion Functions of the membranes: i) Chorion : It

Why is the occurrence of eyelids in amphibians, Why is the occurrence of ey...

Why is the occurrence of eyelids in amphibians in comparison to their absence in fishes and adaptation to terrestrial life? Eyelids associated to lacrimal glands protect and ke

Light-environmental components, LIGHT All of us know that the sun is the ...

LIGHT All of us know that the sun is the ultimate source of energy for all activities in our biosphere. The electromagnetic radiations from the sun supply energy which warms up t

Fertilization - development biology, Fertilization - Development Biology ...

Fertilization - Development Biology Previously you knew the process which leads to the differentiation of the male and female germ cells, the sperm and ova, respectively. In t

Sex, How can I fuck my girlfriend without taking out cum?

How can I fuck my girlfriend without taking out cum?

Risk analysis - animal studies, Animal studies Most toxicological data ...

Animal studies Most toxicological data for risk assessment are derived from the animal studies and  it  is, therefore, essential that these studies be conducted following widel

Surface markings of the heart, The Upper Border of the Heart A:  Mark a ...

The Upper Border of the Heart A:  Mark a point on the lower border of the left second costal cartilage 1.2 cm away from the sternal margin. B:  Mark a point on the upper bord

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd