Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

What are the multiple alleles, What are the multiple alleles? is there domi...

What are the multiple alleles? is there dominance in multiple alleles? The Multiple alleles is the phenomenon in which the similar gene has more than two different alleles (in

Essentials of Human Diseases and Conditions, How do pathological conditions...

How do pathological conditions affect homeostasis of your body?

Type of genetic inheritance that determines abo blood group, What is the ty...

What is the type of genetic inheritance that determines the ABO blood group system? What are the relations of dominance among the involved alleles? The inheritance of the ABO b

Non-succulent perennials, Non-succulent perennials These are actually t...

Non-succulent perennials These are actually the true xerophytes or drought resistants, because they possess a number of morphological, anatomical and physiological characterist

What is manifest squint, What is Manifest Squint (Heterotropia) Manifes...

What is Manifest Squint (Heterotropia) Manifest squint is a deviation of one eye from the normal position when the fusion reflex is present. The subcategories of manifest squin

Alcohol consumption by diabetes patient, Q. Alcohol consumption by diabetes...

Q. Alcohol consumption by diabetes patient? Intake of alcohol should be limited. It is high in calories, lacks essential nutrients and may therefore promote ketoacidosis, hyper

Group selection, The effect of natural selection on colonies or population ...

The effect of natural selection on colonies or population favouring one group in preference to other may be referred to as group selection. A group can be the smallest collection o

What is kingdom protista in diversity of life, What is Kingdom Protista in ...

What is Kingdom Protista in diversity of life? Members of Kingdom Protista are grouped separately from the other eukaryotic kingdoms because most of the organisms have a unicel

Silver point extended below canal orifice, Silver point extended below cana...

Silver point extended below canal orifice -    Ultra-sonic tip -    Microtube tape: The post removal system (PRS) Trephine bur Masserann kit - Do trimming by

Define a technique of implant by using a tissue punch, Using a Tissue Punch...

Using a Tissue Punch The implant heads are located and using a suitable sized tissue punch(depending on the implant diameter), the tissue punch is used and takes a circular pie

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd