Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

Isolation techniques, Differentiate between spread plating and streaking?

Differentiate between spread plating and streaking?

Source of cells for regeneration, Source of Cells for Regeneration It...

Source of Cells for Regeneration It had been considered earlier that interstitial cells constitute a reserve of undifferentiated cells that provide the cellular material for

How can we examine the chromosomes, Is it more indicated for a geneticist d...

Is it more indicated for a geneticist desiring to map the X chromosome of the mother of a given family (the researcher does not have access to her DNA, only access to the genetic m

Define about the physical fitness, Define about the Physical Fitness? P...

Define about the Physical Fitness? Physical fitness is a general term we come across quite often and use it to describe an individual if he or she is able to carry out a variet

What are the effects of protease inhibitors, What are the effects of protea...

What are the effects of protease inhibitors?  In experimental animals, they have been found to be associated with growth inhibition and pancreatic hypertrophy. A negative feedb

Define bioavailability of pyridoxine, Define Bioavailability of pyridoxine?...

Define Bioavailability of pyridoxine? A recent review by Gregory confirms that bioavailability of vitamin B 6 in a mixed  diet is about 7570, with approximately 8% of this tot

Determine the carbon based materials, Carbon Based Materials These incl...

Carbon Based Materials These include Pyrolytic carbon, polycrystalline (Vitreous Carbon), and carbon/silicon interstitial combination. Vitreous Carbon -Solid or porous vitre

Target organ damage, Central Nervous System   Hypertension is one of th...

Central Nervous System   Hypertension is one of the leading causes of cerebrovascular disease. It has been associated with accelerated age related cognitive decline. The most d

Explain about the chromium metabolism, Explain about the Chromium Metabolis...

Explain about the Chromium Metabolism? Chromium appears to be absorbed throughout the small intestine, with absorption being higher in jejunum. The mechanism of absorption has

Taxonomic evidences of evolution, T AXONOMIC EVIDENCES - Taxonomy i...

T AXONOMIC EVIDENCES - Taxonomy is the classification of organism. The gradual development in the complexity of organisms with specialized characters from simpler organisms

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd