Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

Hydropower, Energy from water or hydropower            Hydroelectrici...

Energy from water or hydropower            Hydroelectricity is the energy produce from the kinetic energy of water falling from height. Approximately 25% of world electricity

What is muscle tissue explain briefly, What is Muscle tissue explain briefl...

What is Muscle tissue explain briefly? Remember that a skin cell, in addition to the genetic information that allows it to form into a skin cell, also has all of the genetic in

Describe tr murmur and vsd murmur in details- heart diease, Describe TR Mur...

Describe TR Murmur and VSD murmur in details? TR Murmur :   Characteristic: Holosystolic murmur, loudest at left lower-sternal border and becomes louder with inspiration (Carv

Show the process of chemotaxonomy, Q. Show the process of Chemotaxonomy ? ...

Q. Show the process of Chemotaxonomy ? Chemotaxonomy is a science which uses chemical information as a character for taxonomic purposes. Before we analyse the basis of this mod

What body systems respond to resist the changes, Jennifer has the "stomach ...

Jennifer has the "stomach flu" that is going around campus and has been vomiting profusely for the past 24 hours. Not only has she been unable to keep down fluids or food but she h

Proteases of animals, Proteases of animals From the table you can see ...

Proteases of animals From the table you can see that these exopeptidases and endopeptidases attack specific peptide bonds depending on the chemical group near them. The inacti

What is paediatric clinical literature, What is paediatric clinical literat...

What is paediatric clinical literature The paediatric clinical literature has expanded greatly in its coverage of the wide variety of medical circumstances that can negatively

Closed heart surgery, Closed Heart Surgery Blind operations and access...

Closed Heart Surgery Blind operations and access is obtained into the heart through incision on the ventricular or atrial wall. Commonest closed heart surgery done is m

How do the products of meiosis i differ from of meiosis ii, How do the prod...

How do the products of meiosis I differ from those of meiosis II? In meiosis I, the offspring cells are haploid but every cell contains two copies of the chromosome because th

Class Gastropoda, Class Gastropoda Body asymmetrical, depicts torsion ...

Class Gastropoda Body asymmetrical, depicts torsion or its effects; shell coiled in most, well developed head with radula, large flat foot, gills one or two or with pulmonary

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd