Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

Polyembryony, what are the types of polyembryony?

what are the types of polyembryony?

Sericulture, Sericulture : This is related to silk worms. Sericulture is al...

Sericulture : This is related to silk worms. Sericulture is also known as silk farming. Sericulture is rearing of silkworms for the production of raw silk. There are many types of

Examples of genetic engineering that are improve crop plant, Give three exa...

Give three examples of genetic engineering that are intended to improve crop plants. Genetic engineering of crop plants can improve resistance to pests, retard ripening, impro

Explain elastase, Elastase The inactive  proelastase  is activated by t...

Elastase The inactive  proelastase  is activated by trypsin to the active form elastase. Elastase attacks  peptide  bonds  next  to  the  small amino  acid residues such  3s  g

Compute how much of the absorbance of the bsa, For a sample containing both...

For a sample containing both protein and nucleic acid, the absorbance measured at a particular wavelength will be the sum of contributions from both types of molecule. Using the pr

What is gametogenesis, What is the type of cell division that allows sexual...

What is the type of cell division that allows sexual reproduction? What is gametogenesis? Meiosis is the type of cell division that permits sexual reproduction since it decreas

Determine about benefits of jogging, Determine about benefits of Jogging ...

Determine about benefits of Jogging Jogging gives a sense of wellness to a diabetic patient. The frequency of jogging should be at least 3 days in week with a distance of 2 km

Marine biotechnology, what are the biotechnology techniques used in the fis...

what are the biotechnology techniques used in the fisheries?

Mechanism of stomatal opening, Mechanism of Stomatal Opening It has be...

Mechanism of Stomatal Opening It has been known for over a century that stomata open because of reversible turgor changes in the guard cells. Stomata open when turgor in the g

Explain spoilage of cereals and cereal products, Q. Explain Spoilage of Cer...

Q. Explain Spoilage of Cereals and Cereal Products? Cereals are the main source of energy to human beings. There are several varieties of cereals, of which wheat and rice are t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd