Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

Blood coagulation factor - circulation, Normal 0 false false ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Digestive system - stomach, STOMACH It is wide, J-shaped, placed obl...

STOMACH It is wide, J-shaped, placed obliquely on left side in upper abdominal cavity so left kidney is slightly down ward. It is 30 cm, long and 15 cm. wide. It has g

What is the principle of automated blood cell counters, Question 1 Discuss...

Question 1 Discuss various methods of blood collection in a laboratory. Add a note on collection of blood by using vacutainers. Make a table indicating the color of vacutainer tub

Define placental transfer of nutrients, Define Placental Transfer of Nutrie...

Define Placental Transfer of Nutrients? The placenta is n transitory structure developing during pregnancy and lies implanted on the uterine wall. It is connected with the foet

How does the pancreatic juice help the digestion of lipids, Q. How does the...

Q. How does the pancreatic juice help the digestion of lipids? What is the involved enzyme? The enzyme pancreatic lipase is present in the pancreatic juice this enzyme breaks t

What are the bacteria, Q. What are the bacteria? Bacteria are unicellul...

Q. What are the bacteria? Bacteria are unicellular and prokaryotic beings. Bacteria have simple organization they present an exterior cell wall, plasma membrane, circular DNA w

Grouping of stem cells-totipotent scs, Grouping of Stem Cells: The rang...

Grouping of Stem Cells: The range of differentiation “Potency” is an important property of Stem cells & serves as the basis for classifying cells as : Totipotent SCs -capa

Equivalence point and end point - nutritional biochemistry, Equivalence po...

Equivalence point and end point - Nutritional  Biochemistry? Titrimetric analysis volumetrically measures the amount of reagent, often called a titrant, required to complete a

An experiment with a floating egg, An experiment with a floating egg Pl...

An experiment with a floating egg Place an egg in a glass of fresh water and view it. Next add salt to the water and see if you can float the egg. How does this relate to the f

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd