Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

What is the tentative treatment planning, Tentative treatment planning ...

Tentative treatment planning Once the initial data has been analyed and comprehensive diagnosis and charting of the condition of the mouth has been done, you should formulate a

Vibriosis/campylobacteriosis, Vibriosis/campylobacteriosis This is gen...

Vibriosis/campylobacteriosis This is genital disease of cattle and sheep. The causal organism Campylobacter fetus is a gram negative, curved or spiral shaped bacteria having s

Can you explain pentoses, Q. What are the pentoses? What are the vital role...

Q. What are the pentoses? What are the vital roles of pentoses in DNA and RNA molecules? Pentoses are carbohydrates whole of five carbons. The DNA molecule is made of a sequ

What are cell movements, Cell movements are movements performed by cell str...

Cell movements are movements performed by cell structures, like the movements of cilia and flagella, the pseudopod movements (in amoeba, macrophages, etc.), the cyclosis of the cyt

Tetanus, Tetanus This is an infectious, non-febrile disease of animals...

Tetanus This is an infectious, non-febrile disease of animals and man, and is characterised by spasmodic tetany and hyperaesthesia. The causative agent is Clostridium tetani,

Explain indinavir, Indinavir (IDV, Crixivan) Indinavir has good oral ...

Indinavir (IDV, Crixivan) Indinavir has good oral bioavailability. Indinavir 800 mg combined with ritonavir 100 mg  (both b.i.d. for ease of use) was comparable in effectiven

What bacterial cell structures are used to carry the genes, What bacterial ...

What bacterial cell structures are used to carry the genes intended for genetic engineering? The cells structures in bacteria which carry genes intended for genetic engineering

Water relations in terrestrial environment, Water Relations in Terrestrial ...

Water Relations in Terrestrial Environment Insects are the largest group of metazoans which have most successfully invaded the terrestrial environment. In addition, most arach

Can you explain protease inhibitors, Q. Can you explain Protease inhibitors...

Q. Can you explain Protease inhibitors? Ans. Protease inhibitors are the compounds which are found to some extent in cereal grains such as oats, wheat, barley and mai

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd