Phosphodiesterase inhibitors, Biology

Assignment Help:

Phosphodiesterase Inhibitors and Other Agents

Amrinone and Milrinone are prototypes of type III PDE inhibitors. They decrease the breakdown of cyclic AMP in the myocardium and increase cyclic guanidine monophosphate (cyclic GMP) in vascular smooth muscle, resulting in an increase in myocardial contractility as well as arterial and venous vasodilatation.

Dosage: Milrinone 25-75 microgram/kg bolus over 10 minutes followed by a continuous infusion of 0.375-0.75 microgram/kg. Amrinone is not used because of its propensity to cause Thrombocytopenia.

Side effects: Thrombocytopenia.


Related Discussions:- Phosphodiesterase inhibitors

Describe the distae dissection techniques of surgery , Describe the DistaE ...

Describe the DistaE Dissection Techniques of Surgery? DistaE Dissection (De Bakey Type ZII or Stanford Type B) :  Techniques of Surgery :  The approach is through a left p

Define the redia larva - platyhelminthes, Define the Redia Larva? Redia...

Define the Redia Larva? Redia is the third larval stage in the life cycle of F. heputicn. Redia develops from the germ cell Is of the sporocyst and comes out of the sporoc

What is the normal duration of the menstrual cycle, What is the normal dura...

What is the normal duration of the menstrual cycle? How does the calendar contraceptive method work? The normal duration of the menstrual cycle is 28 days but it can vary betwe

Wind as a medium for dispersal, Wind as a medium for Dispersal Many mic...

Wind as a medium for Dispersal Many microorganisms, fungal spores and bacteria are freely transported over long distances even by moderate winds. In wind pollinated plants, the

Explain about the parkinson''s disease, Explain about the Parkinson's disea...

Explain about the Parkinson's disease? Parkinson's disease is a degenerative central nervous system (CNS) condition characterized by progressive loss of cells within substantia

Extinction of a plant species, How could humans be disadvantaged by the ext...

How could humans be disadvantaged by the extinction of a plant species? The loss of a plant species may deprive humans of any beneficial substances (e.g. drugs) that the specie

Elaborate angiography, Which term is used to describe the process whereby a...

Which term is used to describe the process whereby a catheter is inserted into an individual's heart, a radio-opaque medium is injected & x-ray images are made. Procedure is use

Hydrostatic skeleton, Hydrostatic Skeleton The functioning of the hyd...

Hydrostatic Skeleton The functioning of the hydrostatic skeleton in an animal depends upon the musculature being arranged around an enclosed volume of fluid. After that, cont

Explain intraoral barrier techniques, Q. Explain Intraoral Barrier Techniqu...

Q. Explain Intraoral Barrier Techniques? Rubber dam A rubber dam is used whenever possible for improved vision and access and to reduce dental personnels' exposure to micr

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd