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Non-randomized clinical trial is the clinical trial in which the series of consecutive patients receive a new treatment and those which respond (according to some of the pre-defined criterion) continue to receive it. Those patients who fail to respond receive an alternative, generally the conventional, treatment. The two set of groups are then compared on one or more results variables. One of the problems with such type of a procedure is that patients who respond might be healthier than those patients who do not respond, possibly resulting in an obvious but not real advantage of the treatment.
Interim analyses : An analysis made before the planned end of a clinical trial, typically with the aim of detecting the treatment differences at the early stage and thus preventing
Probabilistic matching is a method developed to maximize the accuracy of the linkage decisions based on the level of agreement and disagreement among the identifiers on different
Case series : It is the series of reports on the condition of the individual patients made by treating physician. Such reports might be helpful and informative for the rare disease
The problematic and enigmatic theory of an inference introduced by the Fisher, which extracts a probability distribution for the parameter on the basis of the data without having f
Model is the description of the supposed structure of a set of observations which can range from a fairly imprecise verbal account to, more commonly, a formalized mathematical exp
Length-biased data is a data which arise when the probability that an item is sampled is proportional to its own length. A main example of this situation occurs in the renewal the
Multiple comparison tests : Procedures for detailed examination of the differences between a set of means, generally after a general hypothesis that they are all equal has been rej
Principal components regression analysis is a process often taken in use to overcome the problem of multicollinearity in the regression, when simply deleting a number of the expla
An investor with a stock portfolio sued his broker, claiming that a lack of diversification in his portfolio had led to poor performance. The data, shown below, are the rates of re
Ha: If hyperlipidemia is believed to be a side effect of second-generation antipsychotics (SGAs), then Hispanic patients with SGAs treatment will have the higher frequency of devel
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