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Infectious bovine rhinotracheitis (IBR)
The disease is caused by a Bovine Herpesvirus -I belonging to the family Herpesviridae and subfamily Alphaherpesvirinae. It is a DNA virus spherical in shape, enveloped and cubical in symmetry, with linear double stranded DNA of 125-235 kbp in size. The virus replicates in the nucleus and hence intra-nuclear inclusion bodies are formed. BHV-1 (infectious bovine rhinotracheitis-IBR; infectious pustular vulvovaginitis-IPVV) causes a variety of diseases in cattle, including rhinotracheitis, vulvovaginitis, abortion or balanoposthitis and conjunctivitis in cattle and buffaloes. Serology and virus isolation showed presence of this disease in India.
Annexin V is a protein that binds to Phosphatidylserine. Why is this useful in the lab? Does it have to do with testing whether the cell is in normal condition?
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