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Q. Illustrate Biological effects of Ochratoxin?
Biological effects: It is associated with the chronic progressive kidney disease in humans known as Balkan endemic nephropathy. There is increased evidence that it can also be considered as a carcinogen with genotoxic property as well as a potent nephrotoxin. The availability of improved methods of analysis has demonstrated that ochratoxin is quite widespread in foods and its presence in human body fluids confirms that there is a significant exposure with the human population. Ochratoxin is immunosuppressive and inhibits protein biosynthesis. Ochratoxin A has been classified by the International Agency for Reseach on Cancer (IARC) as a possible human carcinogen. Low doses as 70μg/kg body weight can induce kidney tumors in male rats. Its oral LD50 in rats is 20 to 22 mg/kg, and it is both hepatotoxic and nephrotoxic.
In 2007, based upon the Survey of Household Spending of 2005, Statistics Canada announced the following weights for the major spending categories tracked by the CPI.
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