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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
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Explain Angio-edema Angio-edema: Swelling of the mucous membranes, tissues beneath the skin or an internal organ because of an allergic reaction.
Explain the Applications of vitamin B 12 Cyanocobalamin is used in the preparation of liquid and dry drug formulations of all kinds. In the animal feed industry, usually co
The most recent blood work of a patient with a diagnosis of acute myelogenous leukemia (AML) reveals thrombocytopenia. Where is the patient most likely to experience abnormal bleed
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ASSISTING IN PROCEDURE OF BIOPSY Biopsies are removal of a small piece of tissue for examination under microscope. Such examinations are called hist to pathological examina
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Define Advantages of Direct Microscopic Count? 1. It is easy, inexpensive and relatively quick method. 2. It gives information regarding size and morphology of microorganism
These are areas where woody shrubs predominate rather then trees. In regions with a Mediterranean type of climate i .e., hot dry summers and cool wet winters, shrubs grow close tog
Q. How different are animal cells from plant cells? While plant cells are eukaryotic, photosynthetic, autotrophic and have chloroplasts and cell wall, the animal cells are hete
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