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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Post pa r turient haemoglobinuria It is also known as puerperal haemoglobinuria or nutritional haemoglobinurea and results in intravascular haemolysis, haemoglobinuria and a
Mention the product and its use formed by each the microbes listed below: i) Lactobacillus ii) Streptococcus iii) Saccharomyces cerevisiae
Explain about the Glycemia or Insulinemia? Preliminary research evidence indicates that there may be beneficial effects in terms of decreased fasting blood glucose/hepatic gluc
General guidelines for use of BONE GRAFTING 1. The surgical site should be prepared, that is it should be free of granulation tissue. 2. For autogenous grafts- the donor sit
Animals of the open water zone The limnetic region of this zone contains certain fishes as well as rotifers, zooplankton such as crustacean and protozoan. In the profundal zo
Setting priorities for action: It is not enough for our actions to be coordinated with events in the outside world; they must reflect our internal needs. Pain can flood conscious
Effects of Cardiogenic Pulmonary Edema Interference with oxygen transfer in the lungs Depression arterial oxygen tension Sense of suffocation and oppression in the
larval forms of sponges
lesson plan practical requirements
FUNCTION S OF TESTOSTERONE - (a) It stimulates the growth and development of male secondary sex organs like the seminal vesicles, prostate and penis. It also helps to maintain
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