Explain the role in insulin formation, Biology

Assignment Help:

Explain the Role in Insulin Formation?

You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.


Related Discussions:- Explain the role in insulin formation

Merits of micro propagation, Merits of Micro Propagation The special m...

Merits of Micro Propagation The special merits of micro propagation are: 1. It considerably increases the rate of multiplication 2. High rate of multiplication can be ma

Tissue, what is the location of connective tissues in our body

what is the location of connective tissues in our body

Biological stress, Biological Stress Since in nature, the various orga...

Biological Stress Since in nature, the various organisms do not live in complete isolation from others, stress to a plant species might also be caused by what other organisms

Explain the metabolic rate of aerobic organisms, Why can the consumption of...

Why can the consumption of molecular oxygen indicate the metabolic rate of aerobic organisms? Molecular oxygen (O2) consumption has direct relation to the cell metabolic rate i

Explain the different types of cells in cell structure , Explain the differ...

Explain the different types of cells in cell structure ? Types of Cells :  Cells can be classified as being either prokaryotic or eukaryotic depending on whether or not a mem

Explain the composition of macconkey agar, Explain the Composition of MacCo...

Explain the Composition of MacConkey Agar? Bactopeptone - 17.0 gm Protease Peptone - 3.0 gm Lactose - 10.0 gm Bile salt mixture - 1.5 gm Sodium chloride - 5.0 gm

Explain gluconeogenesis, Explain Gluconeogenesis Gluconeogenesis (i.e...

Explain Gluconeogenesis Gluconeogenesis (i.e synthesis of  new  glucose)  is  the  synthesis of carbohydrate from  non-carbohydrate, source. The major  substrates for glucone

Explain circulatory support and types of shock, Explain circulatory support...

Explain circulatory support and types of shock? CIRCULATORY SUPPORT 1) A "shock" state is characterised by hypoperfusion of tissue and cellular hypoxia. Circulatory suppo

Explain about gastric ulcers, Q. Explain about Gastric ulcers? Gastric ...

Q. Explain about Gastric ulcers? Gastric ulcers occur in the lesser curvature of the antrum of stomach. A gastric ulcer appears to be caused by reflux of bile and factors that

Phases of cell cycle, The cell goes through many discrete phases before and...

The cell goes through many discrete phases before and after cell division. From this understanding, scientists then identified the four characteristic phases of the cell cycle:

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd