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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Explain Preparation of burette for Estimation of Reducing Sugar by Fehling Soxhlet? Preparation of burette - Take a 50 ml burette. 1. Fix the burette into the burette holder
the evolution of gamatophyte in pteridophyte
Determine the architecture of cell There are over 200 types of cells in the human body, which are assembled into a variety of tissues, such as, the epithelia, connective tissue
Q. Show Measurement of mitral valve? Measurement of mitral valve and gradients across mitral valve are of importance in clinical decision making. Mitral valve area can be measu
Define Nutritional Requirements in Cold and Polar Environment? Energy requirements are the major consideration for providing nutritional support in a cold environment. Energy e
Define Influence of Gardening on the Development of Botany? The influence of gardening on the development of botany may be seen in the work of John Gerard (1545-1612). Gerard p
The cell membrane is a slim semi-permeable membrane which surroundings the cytoplasm of a cell. Membrane function is to defend the integrity of the interior of the cell by allowing
All tissues have some capability for synthesis of the non-essential amino acid remodeling, amino acids and conversion of non-amino acid carbon skeletons into amino acids and other
Explan Ketogenic diet Ketogenic diet: It is occasionally used to facilitate the control of epilepsy. Here, the patient is initially fasted for 48 hours and thereafter,
Do moulds grow better where it is dark or light? This time leave one culture dish in a warm place where it receives light all the time. Place the other dish in a warm dark plac
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