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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Sulphur Cycle - Nutrient Cycles The sulphur cycle is mostly sedimentary except for a short gaseous phase. The large reservoir of sulphur is in the soil and sediment where it i
Define about the Fusarium - Identification of Fungi and Yeasts? Classification Kingdom - Mycetae Division - Amastigomycotina Subdivision - Deuteromycotina Class - D
E. coli strains containing the plasmid pAMP are resistant to ampicillin. Describe how this plasmid functions to bring about resistance.
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Fredrick Griffith published a series of experiments that collectively were dubbed "The Transforming Principle" in 1928. Which of the following stopped him from being able to declar
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What is epistasis? What is the difference between dominant epistasis and recessive epistasis? The Epistasis is the gene interaction in which a gene (the epistatic gene) able to
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How does temperature affect the action of enzymes upon their substrates? There are explained temperature ranges under which enzymes operate and there is a specific temperature
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