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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Define Compartments of Extracellular Fluid? The extracellular fluid compartment is further subdivided into several smaller compartments. These include: 1. Plasma 2. The i
a) What is 'vaso-constriction'? b) What are the effects of vaso-constriction in the skin? a) Vaso-constriction is the reduce in diameter of small arterioles an
Explain Functional property of Gelation/Viscosity Mode of action Protein-protein interactions produce matrix formations and setting Food system Salad dressings,
Which of the following serves as a signal for the ribosome to begin translating the transcript? A. Addition of the poly a tail to the 3' end of the transcript B. Deamination
Introduction: There are different technologies available for dealing with waste water management and excreta. Some are suitable for dealing off-site sanitation and other can b
All the efforts that go into the preparation of instruments are futile if the sterilization process itself is not successful. There is no way of seeing that instruments are sterile
In addition to parasternal and apical transducer position. Subcostal view also provides imaging window in adult patients. The patient is supine with knees flexed to relax the abd
Which one of the following is not a lateral meristem? 1. Intrafascicular cambium 2. Interfascicular cambium 3. Phellogen 4. Intercalary meristem Intercalary m
Difference between aqueous humour and vitreous humour - Aquou s Humour Vitrou s humour 1. Occurs in aquous chamber 2. Wat
Embryonic Development The embryonic stage extends from the second week by the 8th week and is charactrised by formation of placenta, the development of internal organs and ap
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