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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
HOMOPO L YSACCHARIDE S (= HOMOGLYCANS) These are complex carbohydrats that are formed by repeated condensation or polymerisation of only one type of monosaccharide monome
Aortic Valve replacement : The initial steps of the operation have been described earlier. Ascending aorta is cannulated. A single two-stage atrio-venous cannula is inse
Discuss why Obelia is considered to be of special interest in Zoology as an animal showing an intermediate grade of organization.
How the foams are formed? Formation of a foam is dependent on a foaming agent in the continuous phase prior to dispersion of gas. The foaming agent must be adsorbed at the su
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Olericulture: It concerned with the cultivation or development of vegetables yielding plants. Olericulture is the study of vegetable growing, dealing with the culture of non-woody
#qcarrieruestion..
1) a) Initially, how do skeletal muscles (the type of muscle attached to bones) make ATP? b) write the reaction for this procss (Crp +ADP => Cr + ATP) as a ''coupled'' reaction, id
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Conservation and management of biodiversity require measurement of biodiversity because it is important to make choices about "what, where, and how" to conserve. Measurement can be
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