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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Q. What are the characteristics of protozoans that make them resemble animals? Protozoans are unicellular beings with some related characteristics to animal cells. In compar
Little lipophilic (lipid-soluble) hormones distribute across the plasma membrane and then interact with intracellular receptors in the nucleus/cytosol. The receptor
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Explain Casein Casein is an important example of protein, which can be boiled without apparent change in stability. The exceptional stability of casein makes it possible to boi
why protozoass dont have vaccines esp. plasmodiums
Open Type of Circulatory Systems Several non-chordates have thus an open type of circulation - a system in which blood pumped by the heart empties through an artery into an op
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How Cycling is beneficial for proper health Cycling is best for maintenance of fitness. It is a popular exercise and can be done by individual of all ages. Bicycle is required
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