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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
PHARYN X - Commom system between digestive system and respiratory system. In it gullet and glottis present.Gullet leads to oesophagus. Glottis lead to trachea. Wall of p
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write about asexual reproduction in mucor?
De Vega Annuloplasty : Classic De Vega annuloplasty is done using 2'0' double armed polyester suture with pledgets on either end. It starts with one of the needles passed fr
Septa prevent oxygenated and deoxygenated blood. Give reason
What is the aim of specialised assessment The aim of specialised assessment is often to identify a syndrome and specify its probable basis in abnormal brain function. The basi
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Define Eosin - Methylene Blue (EMB) Agar (Levine) Peptone - 10.0 gm Lactose - 5.0 gm Dipotassium - 2.0 gm Hydrogen Phosphate Agar - 13.5 gm Eosin Y - 0.4 gm M
What is the typical feature of the epithelia? How different is it from the connective tissue? The typical feature of the epithelium is the absence or almost absence of space a
Define Role in protein metabolism and growth? Severe vitamin A deficiency results in abnormal RNA metabolism and protein synthesis and hence interferes with growth. Hence vitam
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