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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Apical Ectodermal Ridge (AER) We have described earlier that the AER persists at the tip until the last phalangeal cartilage begins differentiation. The following experiments
Define Nutritional Management of Anorexia Nervosa? The overall goal of nutritional rehabilitation of anorexia nervosa patients is to restore weight, normalize eating pattern, a
what Photoperiodism
Which of the following molecules has more direct effect in learning and memory? A) norepinephrine B) epinephrine C) glutamate D) acetylcholine E) glycine Please leave justification
Citric Acid Cycle The citric acid cycle, also known as tricarboxylic acid (TCA) cycle, lies at the heart of aerobic metabolism. it is involved in the breakdown of all three maj
Explain the Theory or Principle of Determination of the Quality of Milk Milk is an ideal medium for the survival and growth of microorganisms. It contain all the nutrients, i.e
Two important human fossils that throw much light on the human ancestory were discovered in .Olduvai beds in Africa and in central Java respectively. Although the development of bi
Q. Drug Management for gout disease? Drugs are so effective in lowering the serum mate concentration that rigid restriction of dietary purines is rarely necessary. Uricosurie d
Explain Neurologic disease For patients with facial nerve palsy alone, oral doxycycline or amoxicillin may be effective. Patients with other neurologic involvement, such as men
what is vaso-constriction
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