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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
During a routine annual physical,a patient was checked to determine the amount of glucose in the blood.After the assay,It was found that the glucose that the glucose concentration
The calorific value of a fuel can be theoretically determined by using dulong's formula. It is assumed that heat evolved comes from the combustion of carbon, hydrogen, and sulphur
Q. Explain about Mandible? In the mandible, attached keratinized tissue normally atrophies with the underlying bone. As a result there is generally a relatively narrow band of
Dietary Management It must be evident to you that majority of the tuberculosis patients are emancipated and malnourished. Proper dietary management it during and after the inf
WHAT ARE THE DIFFERENT CULTURE MEDIAS USED FOR ISOLATION OF ACTINOMYCETES?
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Atmosphere is a multilayer blanket of various gases such as N2 (78.80%), O2 (20.95%), Ar(0.93%), CO2 (0.03%), water vapor and some other gases. This envelope extends from earth's c
Explain the gradient theoryof experimental embryology
What is mechanical digestion? In molluscs, arthropods, earthworms, birds and vertebrates, in general, which organs respectively participate in this type of digestion? Mechanica
BLOO D CORPUSCLES (= BLOOD CELLS) - Blood corpuscles are of the following three types: Erythrocytes, Leucocytes and Thrombocytes. (A ) Erythrocytes (Red Blood Corpusc
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