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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
write six characteristics of bacteria
ROL E OF WATER - In general water constitutes 60-90% of protoplasm. Average 80%. It forms 2/3 of human body weight, i.e. 66.66%. Due to electrophillic nature of O, wa
For the biological diversity is mitosis or meiosis the more important process? Meiosis is the cell division process that permits the formation of gametes to sexual reproduction
Q. Which organs of the body is part of the human digestive system? The digestive system also known as "systema digestorium" or gastrointestinal system is composed of the digest
What is the name of the cytoplasm division in the end of mitosis? What are the differences in this process between animal and plant cells? Cytoplasm division happens after telo
What is Venous Hum in heart dieases? Characteristic: Continues sound with diastolic component often a higher pitched and louder than the systolic, best heard just above the c
what is the excretory organs of,rat,fish,lizard,frog,cockroach,bird and snail.
what is a plasmid
Total Fertility Rate Total fertility rate (TFR) is the total number of children a women can be expected to bear in a given population if birth rates are constant for at least
Explain the Composition of MacConkey Agar? Bactopeptone - 17.0 gm Protease Peptone - 3.0 gm Lactose - 10.0 gm Bile salt mixture - 1.5 gm Sodium chloride - 5.0 gm
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