Explain the role in insulin formation, Biology

Assignment Help:

Explain the Role in Insulin Formation?

You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.


Related Discussions:- Explain the role in insulin formation

Automated dna sequencing, Automated DNA sequencing is now common place whic...

Automated DNA sequencing is now common place which is based on the chain termination method but using a fluorescent dye attached to an oligonucleotide primer instead of using radio

What are the typical fauna of the tropical forests, What are the typical ve...

What are the typical vegetation and the typical fauna of the tropical forests? In the vegetation of the tropical forests broadleaf evergreen trees predominate. On the top of th

What is pancreatic lipase, What is Pancreatic lipase Pancreatic lipas...

What is Pancreatic lipase Pancreatic lipase  acts on  the dietary triacylglycerols after it has been incorporated into the mixed micelle  in  the  intestinal lumen. The lipa

Explain adaptive radiation and convergence, Adaptive radiation OR convergen...

Adaptive radiation OR convergence Adaptive radiation Explanation of the adaptive radiation process linked to the introduction of a single species and the wide range

#biology, why do ecological models commonly have limited applications ?

why do ecological models commonly have limited applications ?

Viruses, Viruses Viruses are sub cellular, ultramicroscopic infectious...

Viruses Viruses are sub cellular, ultramicroscopic infectious agents of 20 nm-300 nm size range Many of them cause diseases like polio, dengue, small pox, measles, rabies, com

What is modified blalock-taussig shunt explain, What is Modified Blalock-Ta...

What is Modified Blalock-Taussig Shunt explain? This is usually done by interpositioning a PTFE (Goretex) graft of 3.5 or 4 mm in a neonate. It is better done by a left lateral

What is rigor mortis, Q. What is rigor mortis? Dead bodies are at first...

Q. What is rigor mortis? Dead bodies are at first limp. Many hours after death, skeletal muscles undergo a partial contraction that fixes the joints. This condition, called rig

Explain the natural history of coronary artery diseases, Explain the NATURA...

Explain the NATURAL HISTORY OF CORONARY ARTERY DISEASES (GAD)? The natural history of CAD is very important from the preventive point or view. Though the usual manifestations o

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd