Explain the role in insulin formation, Biology

Assignment Help:

Explain the Role in Insulin Formation?

You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.


Related Discussions:- Explain the role in insulin formation

Describe about transposition with large ventricular septal, Describe about...

Describe about Transposition of great arteries with large ventricular septal defect ? Transposition of great arteries with large ventricular septal defect: Usually the intercir

Is the esophagus a muscular organ, Q. Is the esophagus a muscular organ? Wh...

Q. Is the esophagus a muscular organ? Why even in a patient lying totally flat on a hospital bed can the swallowed food reach the stomach? The esophagus is a predominantly musc

Explain objective anti-arrhythmic pacemaker defibrillators, Explain Objecti...

Explain Objective Anti-arrhythmic pacemaker defibrillators? After reading this unit, you should be able to: 1 describes the classification of ant arrhythmic drugs; 2 understand

What does acute disease mean, What does acute disease mean? An sharp di...

What does acute disease mean? An sharp disease is which does not last for a longer duration n has no weakness in the body

#title.ehr, Why have biologists and bioinformaticians embraced the Web as a...

Why have biologists and bioinformaticians embraced the Web as a vehicle for disseminating data so quickly, whereas clinicians and clinical informaticians have been more hesitant to

Humans which distinguish them from other primates, State two characteristic...

State two characteristics of humans which distinguish them from other primates. Two features which differentiate humans from other primates are their upright posture and their

Determine the occurrence of folic acid, Occurrence of folic acid Folic...

Occurrence of folic acid Folic acid is an active principle widely  occurring in the animal and vegetable kingdom. Richest sources are liver, dark  green leafy vegetables, bean

Chordates and non chordates, give an account of ciliary and flagellar move...

give an account of ciliary and flagellar movement in protozoa

5 kingdom system, what r the demerits of 5 kingdom classification?

what r the demerits of 5 kingdom classification?

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd