Explain the role in insulin formation, Biology

Assignment Help:

Explain the Role in Insulin Formation?

You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.


Related Discussions:- Explain the role in insulin formation

Categories of value of biodiversity, Q. Categories of value of biodiversity...

Q. Categories of value of biodiversity? The value of biodiversity is often divided into two main categories: · UTILITARIAN (also known as instrumental, extrinsic, or use) v

Aspirin, ASPIRIN - It is acetylsalicyclic acid (C 6 H 4 (OCOCH) 3 ...

ASPIRIN - It is acetylsalicyclic acid (C 6 H 4 (OCOCH) 3 CH 3 ). It changes in salicyclic acid in body. It is analgesic, antipyratic (fever reducing), anti inflamma

Determine the types of blood, Determine the types of blood There are th...

Determine the types of blood There are three types of blood cells. They are Red Blood Corpuscles (RBC), White Blood Corpuscles (WBC) or leucocytes and blood platelets or thromb

How enzyme to cut two pieces of dna, Critical Thinking Why is it necessary ...

Critical Thinking Why is it necessary to use the same restriction enzyme to cut two pieces of DNA that are to be joined together? As each restriction enzyme recognizes a specif

What is computerised tomography, What is Computerised tomography Comput...

What is Computerised tomography Computerised tomography (CT, but also known as computerised axial tomography, or CAT) provides structural images. To generate brain scans, low l

Ilustrate about corvous caurinus, When we watch animals in the wild, most o...

When we watch animals in the wild, most often we see them foraging for food. The foraging behaviour of animals has been a focus of behavioural studies for many decades. Natura

Can you explain listeriosis, Q. Can you explain Listeriosis? Listeriosi...

Q. Can you explain Listeriosis? Listeriosis is a food borne illness caused by a pathogenic bacterium called Listeria monocytogenes, which is food borne. Listeria monocytogenes

Introduction to population dynamics , Introduction: the term, population i...

Introduction: the term, population is derived from lation word' populus' meaning 'people'. Population is a group organism of same in a particular is at a definite time period.

Determine the principle of neuropsychological assessment, Determine the Pri...

Determine the Principle of neuropsychological assessment The neuropsychological assessment of school age of children and adolescents is not primarily a technological enterpris

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd