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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
D- and L- glucose are Select one: a. stereoisomers b. configurational isomers c. optical isomers d. enantiomers e. all of the above
A lk a l in e indigestion The disease occurs due to the consumption of excessive amount of protein rich concentrate or non protein nitrogenous substance like urea, and is
Explain the False indications of Endodontic Surgery a) Large periapical lesion that could not be eliminated with non-surgical approach. b) Incomplete root formation "open ap
What is an accommodation? Accommodation is the ability of the eye to focus on an object situated at variable distances from the eye. Like a camera, even the eye requires to cha
Precipitation Precipitation literally means falling from a height. In case of water, precipitation includes all forms in which atmospheric moisture descends to earth; rain, sno
Indications for Surgery : Patients with moderate or severe tricuspid regurgitation that is functional will need tricuspid annuloplasty at the time of correction of mitral valve d
Salmonellosis The genus Salmonella comprises nearly 2500 serovars, traditionally based on Kauffman-White scheme in which H (flagelar) and O (somatic) antigens determine the ser
Which of the following is the best definition of the initiation delay that is seen in all organisms? A. Initiation delay is explained as the time it takes for the pre-initiatio
ROL E OF NUCLEIC ACIDS - These are DNA / RNA. Unit is nucleotides. Present in viruses and all cells. DNA is concerned as genetic material. RNA as genetic material
What is scientific investigation?
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