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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Discuss the similarities and differences of transposable elements in E. coli, yeast, plants, and Drosophila.
Explain the Jejuno ileal Bypass and Jaw Wiring? Jejuno-ileal Bypass: Absorptive surface of the small intestines can also be reduced through surgery called the jejuno-ileal by p
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DNA and RNA are polymers composed of repeated units called?
Phosphorylation of fructose-6-phosphate Phosphorylation of fructose-6-phosphate: This is an irreversible reaction, catalyzed byphosphofructo72Snase, (PFK- I) a rate-l
Filer feeding
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I need an idea for a Biology experiment
Explain Precautions for Performing the Completed Coliform Test 1. Aseptic conditions should be adopted while performing the experiment. 2. Destaining is the critical step in
Protein Synthesis The central dogma of modern biochemistry is totally based on the coded information holds within deoxyribonucleic acid (DNA). Double stranded DNA is converted
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