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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Class of Crustacea - Branchiura Branchiura involves only around 130 species of ectoparasitic crustaceans living mostly on the integument and gill cavities of freshwater and ma
in sericulture industry do which stages of silkworm weaver buy? why do they do so?
Determine requirements of Vitamins at high altitude? It is observed that requirement of vitamins is not different as compared to plains. In humans, exposure to high altitude ha
A cell in G1 of interphase has 12 chromosomes. How many chromosomes and DNA molecules will be found per cell when this original cell progresses to the G2?
As heart failure sets in, there is activation of RAS (Fig 2.1). Adrenergic stimulation of beta-1 receptors in juxtaglomerular apparatus of the kidneys results in release of renin.
Q. What are the gynoecium and the androecium? What are the other structures of flowers? Androecium is set of male reproductive structures of flowers it comprehends the stamens
lichens
Q. What do you mean by Nervous System? Structural Organization: CNS + PNS Functional Organization: only concerned with PNS Sensory (Afferent) -> CNS Motor (Effe
what is persons subunit
The second maturation division of the mammalian ovum occurs: 1. Shortly after ovulation before the ovum makes entry into the Fallopian tube 2. Until after the ovum has been p
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