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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Explain the Community ecology of disease? Ebola, hantavirus, bubonic plague, Lyme disease, West Nile virus, rinderpest, and canine distemper virus are all instances of diseases
State the term - Aneurysms Aneurysms are vascular dilations resulting from localised defects in the elasticity of a vessel. They can be visualised as balloon like expansions of
WHAT ARE THE ADVANTAGES & THE DISADVANTAGES OF PROTOZOA?
What is the disease caused by vitamin D deficiency? Which tissue does it affect? The lack of vitamin D causes the disease called as rickets (rachitis), characterized by decalci
Protein Synthesis The central dogma of modern biochemistry is totally based on the coded information holds within deoxyribonucleic acid (DNA). Double stranded DNA is converted
Which is the biological molecule that contains the genetic information that is transmitted hereditarily and controls the cellular functioning? The hereditary molecule that cont
In a test cross: A.alleles of two genes is always involved. B.One parent must be homozygous recessive C.the physical manifestation of a trait can be deterimined. D.both A and C are
Difference between Reproduction System of man and rabbit - S.No. Man Rabbit 1. 2. 3.
Which of the below terms is used to explain the study of factors which influence flow characteristics of blood as it moves through the body? Is it: a) Anginology b) Hemodyna
Regeneration Leading To Asexual Reproduction Regeneration is described as the replacement of the lost parts of the body of an organism. This capacity is present in approximat
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