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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
Define about the Composition of Body Weight? You might have read in previous units that our body weight is composed of muscle bone and fat. Segregating these components of body
Advice on Follow up The patient should adhere to the follow-up schedule strictly. Generally, one week after discharge, then one month and then 3 to 6 months interval, the
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The different organs of the respiratory system Nostrils through which we inhale air in the nasal cavity Pharynx Larynx Trachea (wind pipe) Lungs - Bronchi,
Explain Procedure for Estimation of Sucrose by Fehling Soxhlet Method? Follow the proceedure enumerated herewith and carry out the experiment: 1. Standard titration (Standar
Mineral biofortification of plants One sustainable agricultural approach to reducing the mineral deficiencies in livestock animals is to enrich major staple food crops (rice,
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The epicardial coronary artery system consists of the left and right coronary arteries, which normally arise from ostia located in the left and right sinuses of Valsalva, respectiv
What are the anatomical relationships between the organs of the female reproductive system from the external vulva to the ovaries? The external female genitalia is called the v
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