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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
What is meant by "post-translational modification"? Give examples of post-translational modifications of the following amino acids: a. Serine b. Lysine C. Choose a third amino acid
Describe about the term - Neuropsychological assessment Neuropsychological assessment has its roots in neurology, the branch of medicine that focuses on the nervous system and
Define requirements of Vitamin A for infants? As for vitamin A deficiency, requirement of vitamin A is the most easy to meet as it is abundantly present in green and yellow veg
What is the Mode of Nutrition in mosquito?
What is dry mass? When biomasses are compared often the method of dry mass is used. The dry mass is the total mass less the water mass of an individual. The total mass is also
Q. Anatomy in relation to taxonomy? The use of anatomical* characters in taxonomy began with the development of the microscope which provided the biologist a new tool to observ
Chromosomes, colored bodies, are composed of proteins and DNA; so are chromatids. At metaphase I there are 46 chromosomesaligned in pairs along the human cells equatorial plate. At
Insulin, insulin syringe and insulin devices Insulin is the hormone used to treat diabetes mellitus. Insulin is given in the form of injection, because the gastro intestinal tr
Explain Procedure for Detection of Metanil Yellow? Carry out the exercise following the steps enumerated herewith. 1. Suspend the food sample in water and shake vigorously.
Classification of the Phylum Protozoa up to orders
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