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Explain the Role in Insulin Formation?
You are aware that insulin receptors are present in many cells with their concentration being highest in adipocytes (cells present in adipose tissue) and hepatocytes (liver cells). You also know that insulin receptor has two extracellular alpha-subunits and two extracellular beta-subunits. It is the alpha-subunit to which insulin binds. Once insulin binds to the alpha-subunit of the receptor, a specific phosphorylation of the beta-subunit occurs through a cascade of phosphorylation reactions. This leads to increased insulin sensitivity. The enzyme partly responsible for this phosphorylation is the 'insulin receptor tyrosine kinase'. This enzyme is activated by chromium. In rats, removal of chromium has been shown to result in the loss of kinase-potentiating activity. Besides activating the kinase, chromium also inhibits phosphotyrosine phosphatase-an enzyme responsible for inactivation of insulin receptor. The activation of 'insulin receptor tyrosine kinase and inhibition of 'insulin receptor tyrosine phosphatise by chromium would lead to an increased phosphorylation of the insulin receptor, which is associated with increased insulin sensitivity.
V AGIN A - Median, elastic, muscular tube 7.5 cm long. Open into vestibule by vaginal orffice. The lining forms vaginal rugae. Space between vaginal wall & cervix is forn
Describe how electro negativity can explain why a C-H bond is a no polar covalent bond, but a O-H bond is a polar covalent bond.
Why is Superoxide radical scavenging of beverages such red wine, grape juice measured at 560 nm?
Illustrate the functioning of comprehensive model 1) Provide continuity in understanding developmental progress, or lack thereof, in those disorders that affect neurological de
Risk analysis- Definiton of Food Food : Any substance, whether processed, semi- processed or raw which is intended for human consumption, containing drinks, chewing gu
Radiographic Examination Radiographs are an important tool to evaluate the bone levels, health and implant integrity. Annual radiographs following treatment are recommended in
Zooflagellates – Protozoan Zooflagellates are heterotrophs that are free living, commensals or symbiotic or parasitic in other animals. A number of species eg. Trichonynzpha a
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A wire 50.0 m long and 2.00 mm in diameter is connected to a source with a potential difference of 9.11 V, and the current is found to be 33.7 A. Assume a temperature of 20°C and,
Where in the body is the thyroid gland located? The thyroid is located in the anterior cervical region (frontal neck), in front of the trachea and just below the larynx. It is
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