Already have an account? Get multiple benefits of using own account!
Login in your account..!
Remember me
Don't have an account? Create your account in less than a minutes,
Forgot password? how can I recover my password now!
Enter right registered email to receive password!
Explain the Magnesium Deficiency and Toxicity?
Deficiency of magnesium is rare for two reasons: frstly, the mineral is widely distributed in the foods, secondly, kidney is able to adjust re-absorption of filtered magnesium to body needs. However, Mg depletion occurs in 'various conditions, which either inlpair its intestinal absorption or increase its urinary excretion. Studies have shown that a decline in urinary magnesium excretion during protein- energy malnutrition (PEM) is accompanied by a reduced intestinal absorption of magnesium. The catch-up growth associated with recovery from PEM is achieved only if magnesium supply is increased substantially. Most of the early pathological consequences of depletion are neurologic or neuromuscular defects, some of which probably reflect the influence of magnesium on potassium flux within tissues. Thus, a decline in magnesium status produces anorexia, nausea, muscular weakness, lethargy, staggering and if deficiency is prolonged, weight loss. Progressively increasing with the severity and duration of depletion are manifestations of hyperirritability, hyperexcitability, muscular spasms, and tetany, leading ultimately to convulsions.
An increased susceptibility to audiogenic shock is common in experimental animals. Cardiac arrhythmia and pulmonary oedema frequently have fatal consequences. It has been suggested that a suboptimal magnesium status may be a factor in the etiology of coronary heart disease and hypertension but additional evidence is needed. Hypomagnesernia associated with deficiency represents a plasma Mg levels of less than 1.5 mg/dl. It leads to impaismeilt in Ca and K homeostatsis. Hypocalcernia and hypokalemia have been observed in both experimentally produced and disease-related Mg deficiency. These disturbances are partially caused by hypomagnesemia induced changes in the production and function of PTH. Reduced serum Mg initially stimulates parathyroid gland to produce more PTH, but as deficiency becomes more severe, the sensitivity of parathyroid gland to slow serum Ca concentration is impaired and level of PTH .is low in relation to degree of hypocalcernia. Decreased Mg status has been suggested as a factor contributing to the pathogenesis of several chronic diseases. Both dysrhythmias and myocardial ischemia have been attributed to low Mg intakes. Hypomagnesemia in diabetes may be one of the risk factors in the development of diabetic retinopathy.
Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4
Even though association between GAS pharyngitis and the ARF is fairly well established, the exact pathogenic mechanisms are not clearly understood. However, two mechanisms are post
What are the in-vivo imaging techniques The first of the in-vivo imaging techniques, computer tomography (CT) scanning, came on stream in the early 1970s. As technologies devel
In an investigation to compare the rates at which starch is being broken down by an enzyme (a) what test is used (b) how do you know when the reaction
The role of ATP hydrolysis in actin polymerization is similar to the role of GTP hydrolysis in tubulin polymerization: both serve to weaken the bounds in the polymer and thereby pr
Explain the Dietary Management of Sepsis and MODS? Patients suffering from sepsis and/or resultant multiple system organ dysfunctions are critically ill and admitted in the int
How do the cheek and onion cells visually resemble one another, and why are shapes of squamous cells so different than the onion cells?
Mixed Tricuspid Stenosis and Regurgitation: Rheumatic involvement of the tricuspid valve is often seen in association with involvement of mitral and rarely aortic valve. Isolated
Define Tests of Cardiovascular Endurance? Cardiovascular endurance or aerobic fitness is the ability to exercise continuously for extended periods without tiring. It can be me
Galactosemia Inability of conversion of galactose to glucose results in the accumulation of galactose in the blood - known as galactosemia. The biochemical defect usuall
Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!
whatsapp: +91-977-207-8620
Phone: +91-977-207-8620
Email: [email protected]
All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd