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Fungal Prophylaxis in HSCT
A prospective randomized double- blind trial in 882 adults and children compared prophylaxis with mica fungin 50 mg IV once daily (1 mg/kg for patients weighing <50 kg) to fluconazole 400 mg IV once daily (8 mg/kg for patients weighing <50 kg) during the neutropenic phase of HSCT. The treatment success rate for patients receiving micafungin was 80.0% compared to 73.5% with fluconazole, a statistically important difference, but most patients who failed treatment had received empiric therapy for a suspected, not a confirmed, fungal infection.
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