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Ascorbic Acid (vitamin C)
Although the antiscorbptic (preventing the disease scurvy) effects of citrus hits was known for a long time, the first important step towards its isolation was the discovery of Holst and Frolich in 1907. They reported that guinea pigs, like man and monkey, were also susceptible to scurvy. The isolation of vitamin C was carried out by Zilva during 1917-1927.
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