Explain adefovir dipivoxil, Biology

Assignment Help:

Adefovir dipivoxil (Hepsera) 

This phosphonate nucleoside analog, administered as the oral prodrug, inhibits replication of HBV, including variants resistant to lamivudine. Adefovir treatment of HBeAg-positive or -negative chronic hepatitis B is associated with marked  reductions in HBV DNA levels, aminotransferase normalization in 48% to 72% of patients, and histologic improvements in 53% to 64% at 48 weeks. More prolonged therapy results in higher rates of response; anti-HBeAg seroconversion occurs in 23% by 72 weeks. The antiviral effects of adefovir are similar in lamivudine-susceptible and -resistant HBV infections (MG Peters et al, Gastroenterology 2004; 126:91). Some experts recommend adefovir over lamivudine for long-term treatment of HBeAg-negative or cirrhotic patients because of the high risk of emergence of lamivudine resistance.

 


Related Discussions:- Explain adefovir dipivoxil

Of which type of defense cell do worm infections, Of which type of defense ...

Of which type of defense cell do worm infections stimulate the multiplication? The major leukocytes that generally multiply and participate in the defense against worm infectio

Historical example of management of renewable resources, Define Historical ...

Define Historical example of management of renewable resources? There are fundamental and well developed applications of mathematical and quantitative approaches to the managem

Define the sequence-specific dna binding, Which of the following statements...

Which of the following statements regarding the interactions among sequence-specific DNA binding domains and their recognition sites is incorrect? A. Sequence-specific DNA bind

GRADE 8 SCIENCE, what effects do human technologies have on our water syste...

what effects do human technologies have on our water systems?

Discuss the genetics involved in the inheritance, Casein is the main protei...

Casein is the main protein in milk. There are three types of casein, one of which is beta casein. Beta casein comes in two main variants called A1 and A2. The order of amino acids

What is peristaltic movement role in human digestion, Q. What are peristalt...

Q. What are peristaltic movements? What is their role in human digestion? Peristalsis is the process of synchronized contractions of the muscular wall of the digestive tube, Pe

Explain about bioactive materials, Explain about Bioactive materials Bi...

Explain about Bioactive materials Bioactive materials: Certain glasses, ceramics, and glass-ceramics that contain oxides of silicon, sodium, calcium and phosphorus (SiO 2 , Na

Are mollusc metameric beings, Q Are mollusc metameric beings? Exclusively a...

Q Are mollusc metameric beings? Exclusively analyzing this feature could it be said that molluscs are evolutionarily proximal to nematodes or to annelids? In molluscs there is

Requirements of glutamine in diverticular disease, Q. Requirements of Gluta...

Q. Requirements of Glutamine in diverticular disease? Glutamine: Wile specific nutrients that may have an impact on diverticula disease have not been studied as thoroughly as t

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd