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Adefovir dipivoxil (Hepsera)
This phosphonate nucleoside analog, administered as the oral prodrug, inhibits replication of HBV, including variants resistant to lamivudine. Adefovir treatment of HBeAg-positive or -negative chronic hepatitis B is associated with marked reductions in HBV DNA levels, aminotransferase normalization in 48% to 72% of patients, and histologic improvements in 53% to 64% at 48 weeks. More prolonged therapy results in higher rates of response; anti-HBeAg seroconversion occurs in 23% by 72 weeks. The antiviral effects of adefovir are similar in lamivudine-susceptible and -resistant HBV infections (MG Peters et al, Gastroenterology 2004; 126:91). Some experts recommend adefovir over lamivudine for long-term treatment of HBeAg-negative or cirrhotic patients because of the high risk of emergence of lamivudine resistance.
Water Pollutants - Water Pollution Water pollution can occur on account of any one or more of the following agents: 1. Biological: Pathogens such as virus, bacteria,
What are allosteric enzymes? Allosteric regulators can be allosteric inhibitors or allosteric activators. The interaction among an allosteric enzyme and the allosteric inhibito
Define the Magnesium Requirements in body? Let us learn about the magnesium requirements. Since plant foods are particularly high in magnesium, on a vegetarian diet with plenty
MIDDL E EAR - Protected by tympanic bone. It's cavity is tympanic cavity. It is lined by simple cilliated columnar epithelium. It is connected to naso pharynx by Eu
Explain Cultivation of microorganisms It is for the production of food colourants has attractions, these must be measured against the financial legislative and user constraint
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Physical Weathering Mechanical forces acting upon the rocks cause physical weathering. Temperature fluctuations cause expansion and contraction of rock surface resulting in the
What is digestion? Digestion is the breaking down of larger organic molecules obtained from the diet, e.g. carbohydrates, fats, proteins, into smaller ones, as glucose, fatty a
Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In words, this receptor change intracellular molecules changes a response. Th
how would one determine that the wild type phenotype of a certain trait is due to the action of one or two genes?
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