Explain adefovir dipivoxil, Biology

Assignment Help:

Adefovir dipivoxil (Hepsera) 

This phosphonate nucleoside analog, administered as the oral prodrug, inhibits replication of HBV, including variants resistant to lamivudine. Adefovir treatment of HBeAg-positive or -negative chronic hepatitis B is associated with marked  reductions in HBV DNA levels, aminotransferase normalization in 48% to 72% of patients, and histologic improvements in 53% to 64% at 48 weeks. More prolonged therapy results in higher rates of response; anti-HBeAg seroconversion occurs in 23% by 72 weeks. The antiviral effects of adefovir are similar in lamivudine-susceptible and -resistant HBV infections (MG Peters et al, Gastroenterology 2004; 126:91). Some experts recommend adefovir over lamivudine for long-term treatment of HBeAg-negative or cirrhotic patients because of the high risk of emergence of lamivudine resistance.

 


Related Discussions:- Explain adefovir dipivoxil

Glucagon and glucocorticoids, Important  aspects  related to regulation inc...

Important  aspects  related to regulation include: 1)  The hormones glucagon and glucocorticoids  which are  secreted  during  starvation stimulate  glucose-6-phosphatase to en

Explain methods and vectors, Match each of the methods or vectors below to ...

Match each of the methods or vectors below to an appropriate form of gene therapy, assigning two methods or vectors to each form. Use each method or vector only once. Methods/v

Non-ketotic hyperosmolar diabetic coma, Non-Ketotic Hyperosmolar Diabetic C...

Non-Ketotic Hyperosmolar Diabetic Coma (NKHDC) is another acute complication of diabetes mellitus. In this condition, the coma (loss of consciousness) is developed due to high blo

Exogenous pathway, In the typical Western diet approximately 80-140 G trigl...

In the typical Western diet approximately 80-140 G triglyceride and 0.5-1.5 G cholesterol are eaten daily. Following digestion, absorption and reesterification, triglyceride and c

Division of the exconjugant into daughter paramoecia, Division of the excon...

Division of the exconjugant into daughter paramoecia: Each exconjugant, with a single micronucleus and four macronuclei divides twice and forms four daughter paramoecia. E

Epithelial tissue, conclusion for epithelial tissue when finish experiment?...

conclusion for epithelial tissue when finish experiment?

Coronal disassembly with marginal defect, Coronal Disassembly - If the ...

Coronal Disassembly - If the existing restoration with marginal defect: - The crown was sectioned through the bucco-occlusaly , Christensen crown remover elevate and remove

Define capsule staining (anthony staining method), Define Capsule Staining ...

Define Capsule Staining (Anthony Staining Method)? A rigid, well-organized gelatinous layer called capsule is present outside the cell wall of many bacteria e.g. Streptococus p

Explain third mitotic period, Q. What are the major events of the third mit...

Q. What are the major events of the third mitotic period? The third mitotic period is anaphase. In anaphase the following events occur breaking and duplication of centromeres w

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd