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Adefovir dipivoxil (Hepsera)
This phosphonate nucleoside analog, administered as the oral prodrug, inhibits replication of HBV, including variants resistant to lamivudine. Adefovir treatment of HBeAg-positive or -negative chronic hepatitis B is associated with marked reductions in HBV DNA levels, aminotransferase normalization in 48% to 72% of patients, and histologic improvements in 53% to 64% at 48 weeks. More prolonged therapy results in higher rates of response; anti-HBeAg seroconversion occurs in 23% by 72 weeks. The antiviral effects of adefovir are similar in lamivudine-susceptible and -resistant HBV infections (MG Peters et al, Gastroenterology 2004; 126:91). Some experts recommend adefovir over lamivudine for long-term treatment of HBeAg-negative or cirrhotic patients because of the high risk of emergence of lamivudine resistance.
Tetanus and Diphtheria Everyone who has had a primary series as a child should receive a tetanus-diphtheria toxoid (Td) booster injection once every 10 years. Before traveling
Determine the term - Angiomas Angiomas are congenital collections of abnormal vessels that divert the normal flow of blood. These capillaries, venous, or arteriovenous (A-V) ma
What are the consequences of iodine deficiency disorders? As discussed earlier under signs and symptoms, the consequences of IDD include: mental retardation, other defects in t
Q. What are the hormones secreted by the adrenal cortex? What are their respective functions? The cortical portion of the adrenals secretes hormones of the corticoid (or cortic
Implementation of Nursing Care Provide Bed Rest and Comfort Your major role as a nurse is to provide bed rest to the child and assist the child and parents to understa
Which of the following structures in a vertebrate with a four-chambered heart would have blood with the highest oxygen concentration? And why?
what are the character selection criteria?
Unstable Angina : It is indicative of important reversible myocardial ischaernia that needs urgent evaluation and treatment. Medical management usually relieves symptoms and if t
what are the disadvantages of protozoa?
Q. What are the two divisions of the angiosperms? The angiosperms are divided into dicotyledonous and monocotyledonous.
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