The pharmacist evaluates the available prescription before it can be filled and will review the client's allergies as well as the drug facts. The evaluation involves reviewing potential issues such as allergies, drug interactions (drug-to-drug interactions for patients taking multiple medications or drug-disease interaction for patients with certain health issues). Once the prescription is approved, the prescription can then be filled. If the prescription is not approved, the customer is notified of the denial and asked to return to their physician to resolve the issue.

When the pharmacist fills the approved prescription, the prescription log is updated to: 1) reflect that the requested prescription was filled, and 2) show which pharmacist filled the prescription (i.e. the pharmacist's identification number is noted). The inventory amount is then reduced in the inventory spreadsheet. The prescription slip is filed in the prescription filing cabinet. Finally, the medication, invoice, and medication information sheet are stapled together and left in a filled prescription bin for the sales associate to handle payment collection.