Enzyme-linked receptors, Biology

Assignment Help:

Numerous receptors have intrinsic or tightly related enzyme activity.  On the required of ligand to their extracellular face like receptors undergo a conformational change and activate an enzyme activity.  In  case  of  the  insulin receptor  that  is  a complex  of  two  α- and  two  β-subunits  held  together  through disulfide bonds the polypeptide hormone insulin the ligand binds to the extracellular face of the α-subunits. The receptor then undergoes a conformational modify leading to the autophosphorylation of the cytosolic domain of the β-subunit.  By the specifically hydroxyl groups in the side chains of certain tyrosine residues are phosphorylated with ATP being the phosphate donor.  Phosphorylated   receptor  is  then  identify  by  other proteins   in  the  cytosol   which  in  turn  modulate   various   intracellular   events permitting  the  cell  to  respond  to  the  hormone  appropriately.  Additionally, β-subunit can straight phosphorylate other goal proteins within the cell.

206_22.png

        figure:  Signal transduction through an enzyme-linked receptor such as the insulin receptor.


Related Discussions:- Enzyme-linked receptors

Define the toxicity of vitamin b12, Define the Toxicity of Vitamin B 12 ? ...

Define the Toxicity of Vitamin B 12 ? Intake of 1000 μg vitamin B 12 has never been reported to have any side-effects.  Similar large amounts have been used in some preparati

Describe the non direct approach, Q. Describe the Non Direct Approach? ...

Q. Describe the Non Direct Approach? The counsellor's participation is minimal; here the counsellee freely expresses. The counsellor pays attention to the emotion and attitudes

What are the venous of the valves system, Q. What are the venous of the val...

Q. What are the venous of the valves system? What is their function? The valves of the venous system are structures inside the veins that permit blood to flow only in the norma

Explain indifferences in ionic composition, Indifferences in ionic composit...

Indifferences in ionic composition Answer A. across membranes can be created through the action of ATP driven pumps as long as number of negative and positive ions on remain equal

What are the basic type of neurons, Q. According to the function of the tra...

Q. According to the function of the transmitted neural impulse which are the types of neurons? How different are the concepts of afference and efference of the neural impulse trans

What is dna sequencing, DNA sequencing is the process of reading the nucleo...

DNA sequencing is the process of reading the nucleotide bases in a DNA molecule. It includes any technology or method which is used to verify the order of the four bases- guanine,

Interaction of pyridoxine with ascorbic acid and leucine, Define Interactio...

Define Interaction of pyridoxine with Ascorbic acid and Leucine? Ascorbic acid: Vitamin B 6 metabolism increases with. Higher levels of vitamin C intake. Whole blood a

Rheumatic fever, Rheumatic fever is an immunologically mediated connective ...

Rheumatic fever is an immunologically mediated connective tissue disorder following throat infection with group-A streptococci (GAS). It is characterised by an inflammatory proces

Explain polio, Explain Polio Adults who have not previously been immuni...

Explain Polio Adults who have not previously been immunized against polio should receive a primary series of inactivated polio vaccine (IPV) if traveling to areas where polio i

Define the activation of an agonist during movement, Explain the relationsh...

Explain the relationship between an agonist muscle and its antagonist as it relates to positional control, functional movement and neuromuscular activation. For example, how the th

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd