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A term which covers the large number of techniques for the analysis of the multivariate data which have in common the aim to assess whether or not the set of variables distinguish or discriminate between the two or more groups of the individuals. In medicine, for instance, this type of methods are generally applied to the problem of using optimally the results from the various tests or the observations of various symptoms to make the diagnosis which can only be confirmed perhaps by the post-mortem examination. In the two group case the mainly used method is Fisher's linear discriminant function, in which a linear function of variables giving the maximal separation between the groups is then determined. This results in the classification rule which may be used to assign the new patient to one of the two groups. The derivation of the linear function supposes that the variance-covariance matrices of the two groups are the same. If they are not then a quadratic discriminant function might be essential to distinguish between the groups. Such a function comprises of powers and cross-products of variables. The sample of the observations from which the discriminant function is derived is commonly known as the training set. When more than two groups are involved then it is possible to determine the several linear functions of the variables for separating them. In common the number of such functions which can be derived is the smaller of q and g-1 where q is the number of variables and g is the number of groups. The collection of the linear functions for discrimination is called as canonical discriminant functions or simply as canonical variates.
Continual reassessment method: An approach which applies Bayesian inference for determining the maximum tolerated dose in a phase I trial. The method starts by assuming a logistic
methods of determining trend in time series?
MAZ experiments : The Mixture-amount experiments which include control tests for which the entire amount of the mixture is set to zero. Examples comprise drugs (some patients do no
Probability judgements : Human beings often require assessing the probability which some event will occur and accuracy of these probability judgements often determines success of o
Non parametric maximum likelihood (NPML) is a likelihood approach which does not need the specification of the full parametric family for the data. Usually, the non parametric max
Demographic data: Age: continuous variable Gender: categorical variable with males coded 1, females coded 2. Relationship status: categorical variable 1 to 5. Rational
Jonckheere Terpstra test is the test for detecting particular types of departures from the independence in a contingency table in which both the row and column categories contain
The Null Hypothesis - H0: There is no first order autocorrelation The Alternative Hypothesis - H1: There is first order autocorrelation Durbin-Watson statistic = 1.98307
The Null Hypothesis - H0: There is no heteroscedasticity i.e. β 1 = 0 The Alternative Hypothesis - H1: There is heteroscedasticity i.e. β 1 0 Reject H0 if |t | > t = 1.96
Historical controls : The group of patients treated in the past with the standard therapy, taken in use as the control group for evaluating the new treatment on the present patient
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