Define triglycerides and atherogenesis, Biology

Assignment Help:

Triglyceride accumulation is not a feature of the atherosclerotic plaque but triglyceride-rich lipoproteins also contain cholesterol esters and it is likely that some of these are directly atherogenic.

Hypertriglyceridaemia is associated with alterations in the metabolism of other lipoproteins, which may explain its relationship to CHD risk. It is often inversely related to HDL such that as triglycerides increase, HDL cholesterol concentrations decrease.

In hypertriglyceridaemic individuals there is a preponderance of small, dense LDL particles. A further explanation for the link between plasma triglyceride and CHD risk relates to the association between hypertriglyceridaemia and coagulation factors. Factor VII is an important component of the extrinsic coagulation system and in prospective studies has been shown to be an independent predictor of CHD. Increasing plasma triglycerides are positively correlated with the activity of factor VII and some of the day-to-day variation in factor VII coagulation activity is related to dietary fat intake.

Plasma triglyceride concentration is also positively correlated with activity of plasminogen activator inhibitor 1 (PAI-1). PAI-1 is an inhibitor of plasminogen activation and has been shown to be increased in young myocardial infarction patients.


Related Discussions:- Define triglycerides and atherogenesis

Spinal cord sectioned at the cervical level, Q. How is it explained that a ...

Q. How is it explained that a person with the spinal cord sectioned at the cervical level is still able to perform the patellar reflex? The arch reflex depends only on the inte

Sedative hypnotics - psychological drug dependence, SED A TIV E HYPNOTIC...

SED A TIV E HYPNOTICS - They depress the activity of CNS. Reduce excitement, give feeling of calm. Higher doses induces sleep. Sleep inducing drugs are also called

Muscle, names and locatio

names and locatio

Laboratory tests - evaluation of heart failure, Routine blood tests like ha...

Routine blood tests like haemoglobin, creatinine, electrolytes are useful to plan treatment. More recently the blood natriuretic peptide levels have been used to assess heart failu

Show geniculate bodies of the thalamus, Q Show Geniculate Bodies of the tha...

Q Show Geniculate Bodies of the thalamus? THALAMUS - two large circular shaped masses at "roof" of 3rd brain ventricle. Contains many different nuclei which function as relay

What is the respective importance of water, What is the respective importan...

What is the respective importance of water, carbon and nitrogen for living beings? Water is the major solvent of living beings and it is essential practically for all biochemic

Excreation, the excretory waste products formed breakdown of protein

the excretory waste products formed breakdown of protein

Describe pharmacologic agents in amyl nitrite, Describe Pharmacologic Agent...

Describe Pharmacologic Agents in amyl nitrite ? Amyl Nitrite : It produces vasodilatation which initially results in marked fall in BP and in the next 30-60 seconds there is

How are lipids used as an energy source by the organism, How are lipids use...

How are lipids used as an energy source by the organism? Carbohydrates are the major energy source for aerobic cell respiration. In the absence or deficiency of such substances

Explain biomaterial implantation, Explain biomaterial implantation When...

Explain biomaterial implantation When a biomaterial is introduced into the host, in addition to a host response there is also a material response. Immediately on implantation,

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd