Define regulation of intracellular ca concentration, Biology

Assignment Help:

Define Regulation of intracellular Ca concentration?

The cytoplasmic calcium concentration is regulated by a series of calcium pumps, which either concentrate calcium ions within the intracellular storage sites or extrude them from the cells (where they flow in by diffusion). The physiology of calcium metabolism is primarily directed towards the maintenance of the concentration of ionized calcium in the ECF. This concentration is protected and maintained by a feedback loop through calcium receptors in the parathyroid glands, which control the secretion of parathyroid hormone.

This hormone increases the renal tubular re-absorption of calcium, promotes intestinal calcium absorption by stimulating the renal production of 1,25-dihydroxyvitamin D or calcitriol [1,25- (OH)2D], and, if necessary, resorbs bone. However, the integrity of the system depends critically on vitamin D status; if there is a deficiency of vitamin D, the loss of its calcaemic action leads to a decrease in the ionized calcium and secondary hyperparathyroidism and hypophosphataemia. This is why experimental vitamin D deficiency results in rickets and osteomalacia whereas calcium deficiency gives rise to osteoporosis.

 


Related Discussions:- Define regulation of intracellular ca concentration

Explain hardy weinberg equilibrium., MN blood group in humans is under the ...

MN blood group in humans is under the control of two co-dominant alleles M and N. Blood typing results of a population having of 1349 individuals showed that:  -  363 persons h

Human imapct on the environment, list the long-term and short-term effects ...

list the long-term and short-term effects of forest destruction (a)on hillsides,(b)in the tropics?

What is the embryonic development called, What are the cells produced in th...

What are the cells produced in the first stage of the embryonic development called? The cells that result from the cleavage (the first stage of the embryonic development) are k

Xylem transfer cells, Xylem transfer cells The lateral transport of io...

Xylem transfer cells The lateral transport of ions from root xylem to leaves probably takes place via xylem transfer cells which have two special features: The ce

Explain the primary treatment for managing food allergies, Explain the Prim...

Explain the Primary Treatment for Managing Food Allergies? The primary treatment for managing food allergies is eliminating the offending food or foods. In fact, non-pharmacolo

Is vacuoles easily found in fresh or in salt water, Are protozoans presenti...

Are protozoans presenting contractile, or pulsatile, vacuoles easily found in fresh or in salt water? Fresh water is the less concentrated of solutes than sea water and it (fre

Person and being, What evidence is there that makes it seem humans have mor...

What evidence is there that makes it seem humans have more than a material existence?

Is cancer a disease transmitted to the individual offspring, How are mutage...

How are mutagenic agents related to cancer incidence in a population? Is cancer a disease transmitted to the individual offspring? The exposition of a population to mutagenic a

What is hmp pathway, What is HMP pathway? Give any two points of its signif...

What is HMP pathway? Give any two points of its significance The HMP  is an alternate oxidative pathway for the metabolism of glucose. The significance of the pathway  is that

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd