Define interaction of folate with vitamin b12, Biology

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Define interaction of folate with vitamin B12?

Vitamin B12: For the conversion of folic acid to folinic acid, vitamin B12 is required. Vitamin BIZ deficiency causes a rise in un-conjugated folates and a marked depletion of intracellular conjugated folates. One of the vitamin B12 dependent enzymes, methionine synthase, functions in one of the two folate cycles, namely, the methylation cycle, as you may recall reading earlier. Interruption of the cycle reduces the level of S-adenosylmethionine. Disruption of the methylation cycle also causes lack of DNA biosynthesis and anaemia.


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