Define about the glutathione peroxidases - selenium, Biology

Assignment Help:

Define about the Glutathione peroxidases - Selenium?

The role of selenium in the cytosolic enzyme, glutathione peroxidase (GSHPx), was first illustrated in 1973. Four selenium dependent glutathione peroxidases have been identified and named as Glutathione peroxidases 1-4 (GSHPxs 1-4). During stress, infection, or tissue injury, selenoenzymes may protect against the damaging effects of hydrogen peroxide or oxygen-rich free radicals. This family of enzymes catalyzes the destruction of hydrogen peroxide or lipid hydroperoxides according to the following general reactions:

H2O2 + 2GSH → 2H2O + GSSG

ROOH + 2GSH → ROH + H2O + GSSG

Where, GSH is glutathione and GSSG is its oxidized form.

Thus, from the reaction above, it is evident that the main role of glutathione peroxidases is to reduce hydrogen .peroxide and free hydroperoxides in different cells and tissues by using glutathione (GSH) as the hydrogen donor. Thus, the reactive species of hydroperoxide free radicals are converted into innocuous molecules of water. GSHPx-l is present in virtually all cells, GSHPx-2 is localized in the gastrointestinal tract, and GSHPx-3 is present in plasma while GSHPx-4 is most abundant in testis but present in other tissues also. GSrn4plays a major role in protecting against lipid peroxidation as it is the only intracellular enzyme that can reduce fatty acid hydro peroxide, GSHPx-3 in plasma can also perform this role.


Related Discussions:- Define about the glutathione peroxidases - selenium

Define the different forms of protein energy malnutrition, Define the Diffe...

Define the Different Forms of Protein Energy Malnutrition? The term PEM is used to describe a wide range of clinical conditions ranging 'from the very clinically detectable flo

Do plants have tissue organization and specialized organs, Do plants have t...

Do plants have tissue organization and specialized organs? Plants have specialized organs (as reproductive organs, roots, limbs, leaves) and differentiated tissues (vascular t

Medication for cardiac patients, Medication The patient is advised to ...

Medication The patient is advised to continue antibiotics for a week more after discharge. Other medications prescribed are analgesics (acetaminopen), cough syrup, diuretics

Pollinia and massulae, Pollinia and Massulae In most cases the pollen ...

Pollinia and Massulae In most cases the pollen grains of each tetrad become separated from one another and they lie freely in the pollen sac. In some plants, mostly members of

Set them up using the punnett square, Two gene loci, A and B, assort indepe...

Two gene loci, A and B, assort independently, and alleles A and B are dominant over alleles a and b. Indicate the probability of producing: An aB phenotype from a cross AaBb x AaBB

ELECTRON TRANSPORT SYSTEM AND PHOTORESPIRATION, DESCRIBE ELECTRON TRANSPORT...

DESCRIBE ELECTRON TRANSPORT SYSTEM AND PHOTORESPIRATION

FISHERIES, describe the endoskeleton of fish?

describe the endoskeleton of fish?

Zoology, differences regarding Tiger Planaria and the Iridescent Phyllodoce...

differences regarding Tiger Planaria and the Iridescent Phyllodoce

Explain semi-synthetic gums, Modified or Semi-synthetic Gums These are ...

Modified or Semi-synthetic Gums These are natural polymers, which are chemically modified to give a new product with improved functional properties. These also fall into severa

Define energy requirement during thyphoid, Energy Energy: Fever  is cha...

Energy Energy: Fever  is characterized by  elevation of BMR,  thus caloric requirements are increased.. The increase  in  caloric needs is dependent on  severity  of  infection

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd