Cross over design, Advanced Statistics

Assignment Help:

The type of longitudinal study in which the subjects receive different treatments on the various occasions. Random allocation is required to determine the order in which the treatments are received. The simplest such design includes two groups of the subjects, one of which receives each of the two treatments, A and B, in the order AB, while the other takes them in the reverse order. This is called as a two-by-two crossover design. While the treatment comparison is 'within-subject' rather than the 'between-subject', it is likely to need fewer subjects to achieve the given power. The study of such designs is not necessarily straight- forward because of the possibility of the carryover effects, that is left over effects of the treatment received on the first occasion which remain present into the second occasion. An attempt to minimize this problem is many times made by including the wash-out period between the two treatment occasions. Some of the authorities have suggested that this type of design should only be used if such carryover effects can be ruled out a priori. Crossover designs are only applicable to the chronic conditions for which short-term relief of the symptoms is the goal rather than a cure of it.


Related Discussions:- Cross over design

Traditional linear model, What is a Generalized Linear Model? A traditional...

What is a Generalized Linear Model? A traditional linear model is of the form where Yi is the response variable for the ith observation, xi is a column vector of explanator

Factorial moment generating function, The function of a variable t which, w...

The function of a variable t which, when extended formally as a power series in t, yields factorial moments as the coefficients of the respective powers. If the P(t) is probability

Pattern recognition, Pattern recognition is a term for a technology that r...

Pattern recognition is a term for a technology that recognizes and analyses patterns automatically by machine and which has been used successfully in many areas of application inc

Describe jonckheere terpstra test, Jonckheere Terpstra test  is the test fo...

Jonckheere Terpstra test  is the test for detecting particular types of departures from the independence in a contingency table in which both the row and column categories contain

Define hazard function, Hazard function : The risk which an individual expe...

Hazard function : The risk which an individual experiences an event in a small time interval, given that the individual has survived up to the starting of the interval. It is th

Alternative hypotheses and spss calculation, 1) Question on the first day q...

1) Question on the first day questionnaire asked students to rate their response to the question Are you deeply moved by the arts or music? Assume the population that is sampled

Population averaged models, Population averaged models are the models for ...

Population averaged models are the models for kind of clustered data in which the marginal expectation of response variable is the main focus of interest. An alternative approach

Cellular proliferation models, Cellular proliferation models : Models are u...

Cellular proliferation models : Models are used to describe the growth of the  cell populations. One of the example is the deterministic model   where N(t) is the number of cel

Finite population correction, This term sometimes used to describe the extr...

This term sometimes used to describe the extra factor in variance of the sample mean when n sample values are drawn without the replacement from the finite population of size N. Th

Bivariate survival data, Bivariate survival data : The data in which the tw...

Bivariate survival data : The data in which the two related survival times are of interest. For instance, in familial studies of disease incidence, data might be available on the a

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd