With the development of electron microscopy, it was possible to have an in depth knowledge of the interface between the implant and the tissues. Branemark was the pioneer in the field of implantology. While conducting studies regarding the vascularity of bone marrow in rabbit fibula, he discovered the phenomenon named "osseointegration" which was later defined as "a direct structural and functional connection between ordered, living bone, and the surface of a load carrying implant". He developed the first two stage threaded titanium implant. Brånemark developed the Nobelpharma Implant Company of Goteberg, Sweden. The implant system began with research dating back to 1965. Brånemark introduced their first commercial implant in 1982 made of pure titanium. They quickly became the standard by which all root form implants and manufacturers were to be measured. It took only a few years for him to reverse the image of dental implants from experimental and risky to credible and promising.