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In animals, some of bacteria and fungi, and the first step in tetrapyrrole synthesis is the condensation of the amino acid glycine with succinyl CoA (an intermediate of the citric acid cycle) to built ALA (aminolaevulinic acid). This reaction is catalyzed by the enzyme ALA synthase that needed the coenzyme pyridoxal phosphate and is situated in the mitochondria of eukaryotes. This committed phase in the pathway is subject to regulation. Synthesis of the ALA synthase is feedback-inhibited by heme. In algae, plants and various bacteria there is an alternative route for ALA synthesis which have the conversion of the intact five-carbon skeleton of glutamate in a series of three steps to yield ALA. In all organisms there are two molecules of ALA then condensing to form porphobilinogen in a reaction catalyzed by ALA dehydratase (also called as porphobilinogen synthase). Inhibition of this enzyme by lead is one of the main manifestations of acute lead poisoning.
Cholesterol is a steroid. It is very significant constituentof cell membranes in mammals, it modulates their fluidity. Cholesterol is also the precursor of steroid hormones such
If baroreceptors are primed to detect blood pressure changes and compensate for them, how is it that some patients suffer from chronic hypertension?
Explain functional properties of protein hydrolysis Hydrolysis of food proteins using proteases (trypsin, chymootrypsin, papain and thermolysin) alters their functional propert
a) Name the mineral elements needed by (i) bones, (ii) red blood cells, (iii) the thyroid gland b) Which of these elements is (i) present in milk, (b) lacking in milk?
HIND BRAIN - 1 . CEREBELLUM - Little part, lies below the posterior part of cerebrum & above the medulla oblongeta. It conists of median lobe vermis & 2 lat
Describe three mechanisms cells use to produce diversity of ion channel structure and function.
How much Minerals should be taken for management of obesity? A diet high in sodium may promote retention of fluid in the body. Moderate restriction in the use of common/table s
Explain Micafungin sodium Micafungin sodium (Mycamine - Astellas), the second echinocandin antifungal1 to become available in the US, has been approved by the FDA for intraveno
What is an open circulatory system? Open circulatory system is the one in which blood does not circulate only in blood vessels but it also falls in cavities that irrigate tissu
You will be learning about vitamins and minerals (micronutrients) over a 2 week span. Remember phytochemicals from the Controversy section of chapter 2? They are not vitamins, b
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