Angiotensin receptor blockers, Biology

Assignment Help:

Angiotensin receptor blockers block the final common pathway and provide a means of complete blockade of the system.

One of two subtypes of AII receptors, the AT1 receptor produces vasoconstriction and induces muscle cell proliferation when activated; the AT2 receptor produces antiproliferative effects upon activation. Currently available ARBs selectively block the AT1 receptor, producing vasodilatation and inhibiting muscle cell proliferation.

However, these agents do not produce increases in bradykinin, prostaglandins, and nitric oxide in the heart, blood vessels, and other tissues. They   should be considered as alternatives to ACE inhibitors in ACE-intolerant patients especially patients with chronic dry irritating cough and angiedema. Another potential use is to counteract ACE escape, the attenuation of the benefits of ACE inhibition that may occur with time.

Various agents available are losartan, valsartan, irbesartan, candesartan, telmisartan and eprosartan.


Related Discussions:- Angiotensin receptor blockers

What are compound eyes, What are compound eyes? Arthropods have compoun...

What are compound eyes? Arthropods have compound eyes made of many visual units called ommatidia. Every ommatidium transmits visual information by the optic nerve to the brain,

Calculate how much of the stock solution, A 15 mM solution of potassium chl...

A 15 mM solution of potassium chloride is needed for and experiment. The only liquid stock that is a available is a 1 M solution. Calculate how much of the stock solution is needed

Explain enzyme glutamate oxaloacetate, Enzyme  glutamate oxaloacetate tran...

Enzyme  glutamate oxaloacetate transaminase catalyzes  the  reaction between glutamate and oxaloacetate with the formation of a-ketoglutarate and aspartate due to transfer  of one

Segments of environment:, Segments of Environment: The environment ...

Segments of Environment: The environment is not a simple distribution of gases but is highly complex and structured. It comprises of four segments:   Lithosphere

ECOLOGICAL PYRAMIDS, Ask questionLIMITATION OF ECOLOGICAL PYRAMIDS #Minimu...

Ask questionLIMITATION OF ECOLOGICAL PYRAMIDS #Minimum 100 words accepted#

Determine the sexual arousal mechanism, How does the sexual arousal mechani...

How does the sexual arousal mechanism in women facilitate fecundation? During sexual arousal in women the vagina secretes substances to neutralize its acidity therefore allowin

Study of human age pyramids, Q. What are the analyses provided by the study...

Q. What are the analyses provided by the study of human age pyramids? The study of human age pyramids able to provide the following analyses, proportion of individuals at an ec

Sexual reproduction, Normal 0 false false false EN-IN ...

Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4

Define the micronutrient deficiencies, Define the Micronutrient Deficiencie...

Define the Micronutrient Deficiencies? In the previous section, we learnt about macronutrient deficiencies i.e. protein energy malnutrition in children. We are now aware that t

What its population growth rate, A population has 350 births per 1000 indiv...

A population has 350 births per 1000 individuals and 320 deaths per 1000 individuals. 1. what its population growth rate? 2. Intrinsic rate of increase? 3. Doubling time? 4. Derive

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd