Angiotensin receptor blockers, Biology

Assignment Help:

Angiotensin receptor blockers block the final common pathway and provide a means of complete blockade of the system.

One of two subtypes of AII receptors, the AT1 receptor produces vasoconstriction and induces muscle cell proliferation when activated; the AT2 receptor produces antiproliferative effects upon activation. Currently available ARBs selectively block the AT1 receptor, producing vasodilatation and inhibiting muscle cell proliferation.

However, these agents do not produce increases in bradykinin, prostaglandins, and nitric oxide in the heart, blood vessels, and other tissues. They   should be considered as alternatives to ACE inhibitors in ACE-intolerant patients especially patients with chronic dry irritating cough and angiedema. Another potential use is to counteract ACE escape, the attenuation of the benefits of ACE inhibition that may occur with time.

Various agents available are losartan, valsartan, irbesartan, candesartan, telmisartan and eprosartan.


Related Discussions:- Angiotensin receptor blockers

Define measuring body composition- multiple isotope dilution, Define measur...

Define measuring body composition- Multiple isotope Dilution? Multiple isotope dilution (Total and extracellular body water): It is based on the principle that certain substanc

How are the female gametes of gymnosperms formed, Q. How are the female gam...

Q. How are the female gametes of gymnosperms formed? What is the relationship between this process and the concept of alternation of generations? In the female strobiles (cones

Define the risk reduction in cardiovascular disease, Q. Define the Risk red...

Q. Define the Risk reduction in cardiovascular disease? Ans. Weight loss by caloric restriction diets has been shown to decrease plasma CRP levels. Additional data indicat

What is hansen disease, What is Hansen's disease (etiological agent, mode o...

What is Hansen's disease (etiological agent, mode of transmission, clinical manifestations and prevention)? The etiological agent of Hansen's disease is bacteria known as Mycob

What is single cross between two mountain rabbits, In mountain rabbits, the...

In mountain rabbits, the EL-1 gene is located on chromosome 3. Seven alleles of this gene have been identified in the population. With respect to EL-1, what is the maximum number o

Bque, what is working of heart

what is working of heart

Speciation, Ernst Mayr, for whom, species and species problem have been the...

Ernst Mayr, for whom, species and species problem have been the main concern of research, points out that speciation, the multiplication of species, that is division of one parent

Explain precautions for gram staining of bacterial cultures, Explain Precau...

Explain Precautions for Gram Staining of Bacterial Cultures? 1. Heat fix the smear, otherwise cells would be washed off. 2. Fresh 24 hrs old culture should be used. Gram var

Why is carbon monoxide toxic for humans, Why is carbon monoxide toxic for h...

Why is carbon monoxide toxic for humans? Hemoglobin "likes" carbon monoxide (CO) much more than it likes oxygen. When there is carbon monoxide in the inhaled air it binds to he

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd