Angiotensin receptor blockers, Biology

Assignment Help:

Angiotensin receptor blockers block the final common pathway and provide a means of complete blockade of the system.

One of two subtypes of AII receptors, the AT1 receptor produces vasoconstriction and induces muscle cell proliferation when activated; the AT2 receptor produces antiproliferative effects upon activation. Currently available ARBs selectively block the AT1 receptor, producing vasodilatation and inhibiting muscle cell proliferation.

However, these agents do not produce increases in bradykinin, prostaglandins, and nitric oxide in the heart, blood vessels, and other tissues. They   should be considered as alternatives to ACE inhibitors in ACE-intolerant patients especially patients with chronic dry irritating cough and angiedema. Another potential use is to counteract ACE escape, the attenuation of the benefits of ACE inhibition that may occur with time.

Various agents available are losartan, valsartan, irbesartan, candesartan, telmisartan and eprosartan.


Related Discussions:- Angiotensin receptor blockers

Explain about post-operative pain, Post-operative pain  There is some d...

Post-operative pain  There is some discomfort for about 24-48 hours. Persistent pain for a longer duration, with swelling, may indicate possible infection around the implant an

Explain class bivalvia in animal kingdom, Explain Class Bivalvia in animal ...

Explain Class Bivalvia in animal kingdom? This name of this Class reflects the group's most distinguishing feature. Clams, oysters, scallops and mussels all have two shells tha

How many chromosomes and chromatin strands, Drosophila has 4 bivalents (hom...

Drosophila has 4 bivalents (homologous chromosomes) formed at Meiosis I. How many chromosomes and chromatin strands are present in each of the following stages- Anaphase of mito

Agricultural activities - cause of air pollution, Agricultural activities -...

Agricultural activities - Cause of Air Pollution Agricultural activities too are a major cause of air pollution. About 60 to 65% of carbon dioxide is produced from burning of

Gene targeting in es cells, Gene targeting in ES cells: In some of the li...

Gene targeting in ES cells: In some of the livestock species pro-nuclear injection cannot be used to modify the animals' own genes due to various reasons especially non availabil

Nervous tissue and its components, NE R V OU S TISSUE The nervous...

NE R V OU S TISSUE The nervous tissue in general develops from the ectoderm of the embryo, but the microgliocytes. It does not have a matrix. The special properti

How can nutrients are classified, According to their functions how can nutr...

According to their functions how can nutrients are classified? One possible and utile functional classification for nutrients is the one that divides them into energetic, struc

Explain the primary function of blood, Explain the primary function of bloo...

Explain the primary function of blood? The primary function of the blood to transport oxygen from the lungs to body tissues for interior respiration. The blood helps in maintai

How to measure a quality of water sample, various parameters which are used...

various parameters which are used in water quality measurement

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd