Angiotensin receptor blockers, Biology

Assignment Help:

Angiotensin receptor blockers block the final common pathway and provide a means of complete blockade of the system.

One of two subtypes of AII receptors, the AT1 receptor produces vasoconstriction and induces muscle cell proliferation when activated; the AT2 receptor produces antiproliferative effects upon activation. Currently available ARBs selectively block the AT1 receptor, producing vasodilatation and inhibiting muscle cell proliferation.

However, these agents do not produce increases in bradykinin, prostaglandins, and nitric oxide in the heart, blood vessels, and other tissues. They   should be considered as alternatives to ACE inhibitors in ACE-intolerant patients especially patients with chronic dry irritating cough and angiedema. Another potential use is to counteract ACE escape, the attenuation of the benefits of ACE inhibition that may occur with time.

Various agents available are losartan, valsartan, irbesartan, candesartan, telmisartan and eprosartan.


Related Discussions:- Angiotensin receptor blockers

Interspecific sterility, In interspecific sterility, the failure in mating ...

In interspecific sterility, the failure in mating occurs because of inability of the sperm to reach the egg in animals and the pollen to reach ovules in plants. In plailts interspe

Cranial nerves, The cranial nerves are composed of twelve pairs of nerves...

The cranial nerves are composed of twelve pairs of nerves which emanate from the nervous tissue of brain. In order to reach their targets they should ultimately exit/enter the cr

Biochemical changes - consequences of aging, Biochemical Changes - Conseque...

Biochemical Changes - Consequences of Aging Several biochemical changes are correlated with aging. Detailed biochemical studies in rats have been carried out by Prof. M.S. Kan

What is the destination of the branchial clefts in humans, What is the dest...

What is the destination of the branchial clefts in humans? In humans the branchial clefts situated in the anterior region of the pharynx (also called as pharyngeal clefts) are

Is dwarf pampas grass invasive, Is dwarf pampas grass invasive? No. the...

Is dwarf pampas grass invasive? No. the root system is shallow and extends only as far as the plant is large. Though if the irrigation system is installed poorly and the pipes

Formation of gametes, In his experiments, Mendel noted that when two traits...

In his experiments, Mendel noted that when two traits are involved in a genetic cross, they are inherited independently of each other. The reason for this is that A. genes on the s

What do you mean by myocarditis, Q. What do you mean by Myocarditis? My...

Q. What do you mean by Myocarditis? Myocarditis is defined as inflammation of the myocardium. The most common cause is Coxsackie B virus infection. But it can also be due to

Explain differential media - culture media, Explain Differential Media - Cu...

Explain Differential Media - Culture Media? It allows differentiation among morphologically and biochemically related group of organisms. It contains certain ingredients which

What is the typical vegetation of the grasslands, What is the typical veget...

What is the typical vegetation of the grasslands? The Grasslands are mainly formed of herbaceous (nonwoody) vegetation: grass, small trees and bushes.

Define assessment of calcium status and calcium requirements, Define Assess...

Define Assessment of Calcium Status and Calcium Requirements? There is no biochemical indicator, which can clearly reflect calcium status. It has also been seen that in case of

Write Your Message!

Captcha
Free Assignment Quote

Assured A++ Grade

Get guaranteed satisfaction & time on delivery in every assignment order you paid with us! We ensure premium quality solution document along with free turntin report!

All rights reserved! Copyrights ©2019-2020 ExpertsMind IT Educational Pvt Ltd