Working in a mouse genetics lab

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Imagine that your friend is working in a mouse genetics lab at CSU. She observes a mutant phenotype with a yellow coat that differs from the white coat of the mice she normally works with. When she crosses the yellow mice with inbred white mice, she gets a 1:1 ratio of yellow and white offspring, making her think that the yellow mice are heterozygous. However, when she crosses two apparently heterozygous yellow mice she gets an approximately 2:1 ratio of yellow to white mice, rather than the more familiar 3:1 Mendelian ratio. Her advisor does not believe her results and sends her back to the mouse room to generate more data. After rearing hundreds and hundreds of mice, your friend has great statistical confidence that the ratio is very close to 2:1 and definitely not 3:1, but she still does not know how to explain it to her advisor. Can you provide an explanation that is consistent with your friendâs data and the principles of Mendelian segregation to get her out of the mouse room

Reference no: EM131484779

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