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1. Describe why topoisomerases are needed in eucaryotic cells even though eucaryotic DNA molecules are linear, not circular like procaryotic DNA molecules.2.a) What is the name of an antibacterial antibiotic which acts by affecting topoisomerase?b) What is the name of an anticancer drug which acts by affecting topoisomerase?3. Topoisomerases are involved in DNA replication, so it makes sense that a drug which messes up topoisomerase activity stops the cell from reproducing. However, in many cases, the cell not only stops reproducing but is also killed because its DNA is broken. Suggest a mechanism for how messing up topoisomerase activity could cause this effect on the cell's DNA.
Rifamycin and actinomycin D are two antibiotics derived from bacterium Streptomyces. Rifamycin binds to b subunit of E. coli RNA polymerase and interferes with formation of the first phosphodiester bond in the RNA chain.
While you measure the genotype frequencies of the population you get the following data. What will the frequency of Aa be in the next generation.
Think about a population in which the frequency of allele A is p=0.7 and the frequency of allele a is q=0.3, and where the alleles are codominant.
Both proto-oncogenes and tumor suppressor genes can interact with transcription factors involved cell division. Determine the fundamental difference in how the two function?
why the sequences are read in different reading frames.
Using the data given in table below draw a Lineweaver-Burk plot.
How might Lucy conceive a child with just one ovary and one uterine tube, widely separated on opposite sides of the pelvis like this.
It is the accumulation of acetyaldehyde that results in flushed face, dizziness, and light headedness responses that are associated with ethanol intoxication.
After WWII, DDT was widely used to kill mosquitoes. Spraying DDT was effective for some years, but despite continuous spraying at ever increasing concentrations of DDT,
The ATP solution used in this experiment had a concentration of 0.25 percent, which represents the normal physiological cytoplasmic concentration of ATP.
What phenotypes will you suppose among the 1024 offspring, and how many of each phenotype would you expect.Suppose that a cross is made between a fly with normal wings.
A patient displaying the enlargement of lateral and third ventricles, however no enlargement of fourth ventricle. Explain what do you conclude.
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