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1. If a replication error that creates an A-G mismatch is not repaired before the next round of replication, what will be the sequences of the 2 daughter DNAs after replication
2.Transcription-coupled repair occurs more rapidly than global genome repair. Why?
3. Glycosylases flip out damaged bases but Rad4/XPC flips out undamaged bases across from sites of damage. Given the roles of these different proteins, why does this difference make sense?
4.Why is error-prone repair useful, even if it introduces mutations?
5. Cancer cells from patients with HNPCC show dramatic changes in the lengths of microsatellite loci. Explain.
6. Explain why large gaps and double-strand breaks are preferentially repaired by recombination, but a stalled replication fork can utilize either excision repair or recombination-repair pathways.
7.Many lymphoid cancers in patients with diseases such as NBS are linked to chromosomal translocations. Explain.
Purple eye color in fruit flies is an autosomal recessive trait whereas the normal eye color in fruit files (brick color) is an autosomal dominant trait.
Use the cleland representation create the reaction progress of thrombin, a serene protease using a ping pong mechanism on the hydrolysis of the substrate Ala-Arg-Gly-Ala
Describe the intimate relationship in the hypothalamus of the brain and pituitary gland that sits just below it. Although the pituitary is called the master gland because of its influence over other endocrine glands,
find out the major pathway of glycine degradation. you find that the amino acid serine contains the most radioactivity, and that both the Calpha and Cbeta carbons of the serine residue are labeled with 13C. Explain these observations.
What information does it not provide that may be useful for deciding on conservation efforts. What are the genotypes of the parents.
In analyzing a big sample of yeast colonies on a petri dish, a geneticist finds an abnormal looking colony that is very small. This small colony was crossed with wild type, and products of meiosis were spread on a plate to produce colonies.
Reactive oxygen species are unstable, or reactive, compounds that result from partial reduction of oxygen. Reactive oxygen species can cause damage to molecules, including membrane lipids and nucleic acids.
Suppose if an AaBbCcdd male mates with an AaBbCCDD female find the minimum and maximum number of ridge-producing genes possible in one of their children?
Explain why it is critical for mitosis and meiosis to follow precise processes but not for cytokinesis?
calculate the Shannon-Wiener index (H0) for each plot. I've broken the data above into three separate tables for your calculations. Fill in the following three tables and calculate H0 for each plot.
What is the benefit of a mouse liver cDNA library over a genomic library made from mouse liver. What is a lipid? Explain the different classes of lipids. What is a fatty acid? What makes acid saturated or unsaturated.
Assume you are creating a PCR reaction mixture with a total volume of 50µL. The primer set concentration is 1µl primer/10µl reaction volume.
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