What study design is most appropriate

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Reference no: EM132624763

Question 1: An investigator wants to assess whether smoking is a risk factor for pancreatic cancer. Electronic medical records at a local hospital will be used to identify 50 patients with pancreatic cancer. One hundred patients who are similar but free of pancreatic cancer will also be selected. Each participant's medical record will be analyzed for smoking history. Identify the type of study proposed and indicate its specific strengths and weaknesses

Question 2: What is the most likely source of bias in the study described in Problem 1?

Question 3: A study is planned to investigate risk factors for sudden cardiac death. A cohort of men and women between the ages of 35 and 70 is enrolled and followed for up to 20 years. As part of the study, participants provide data on demographic and behavioral characteristics; they also undergo testing for cardiac function and provide blood samples to assess lipid profiles and other biomarkers. A new measure of inflammation is hypothesized to be related to sudden cardiac death. What study design is most appropriate to assess the association between the new biomarker and sudden cardiac death? Describe its strengths and weaknesses.

Question 4: An investigator wants to assess the association between caffeine consumption and impaired glucose tolerance, a precursor to diabetes. A study is planned to include 70 participants. Each participant will be surveyed with regard to their daily caffeine consumption. In addition, each participant will submit a blood sample that will be used to measure his or her glucose level. Identify the type of study proposed and indicate its specific strengths and weaknesses.

Question 5: Could the study described in Problem 4 be designed a randomized clinical trial? If so, briefly outline the study design; if not, describe the barriers.

Question 6: In 1940, 2000 women working in a factory were recruited into a study. Half of the women worked in manufacturing and half in administrative offices. The incidence of bone cancer through 1970 among the 1000 women working in manufacturing was com-pared with that of the 1000 women working in admin-istrative offices. 'Thirty of the women in manufacturing developed bone cancer as compared to 9 of the women in administrative offices. This study is an example of a
a. randomized controlled trial
b. case-control study
c. cohort study
d. crossover trial

Question 7: An investigator reviewed the medical records of 200 children seen for care at Boston Medical Center in the past year who were between the ages of S and 12 years old, and identified 40 with asthma. He also identified 40 children of the same ages who were free of asthma. Each child and his or her family were in-terviewed to assess whether there might be an associ-ation between certain environmental factors, such as exposure to second-hand smoke, and asthma. This study is an example of a
a. randomized controlled trial
b. case-control study
c. cohort study
d. crossover trial

Reference no: EM132624763

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