Reference no: EM133472083
Assignment:
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Protein: Insulin receptor
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Ligand : Insulin
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PDB: 6SOF
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The overall structure of your presentation should be organised to present the information on your chosen protein-ligand interaction in a clear, logical fashion. Some suggested points to address are listed below:
What are the protein and ligand to be presented?
Where does the interaction between the protein and ligand occur? (Describe which species, cell type or organ the interaction occurs)
What is the primary biological function of the interaction (i.e. part of immune responses, cell signalling, metabolism, etc)
Describe the molecular interaction in greater molecular detail, including details such as:
o What are the characteristic motifs and/or domains present in the protein?
o Which amino acids of the protein are involved in interacting with the ligand?
o What triggers the interaction?
o Does the interaction change the conformation/structure of the protein and/ or ligand?
o Are there cofactors required for this interaction or inhibitors that can block it?
Other relevant or interesting information related to the interaction not covered above, such
as:
o Are there any post-translational modifications of the protein that impact the interaction?
o Does this interaction vary in different cells or organisms?
o Are there mutations that affect the protein and /or cause genetic disease?