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Tay-Sachs disease is an autosomal recessive neurological disorder that is fatal in infancy. Despite its invariably lethal effect, Tay-Sachs disease occurs at very high frequency in some Central and Eastern European (Ashkenazi) Jewish populations. In certain Ashkenazi populations, 1 in 650 infants has Tay-Sachs disease. Population biologists believe the high frequency is a consequence of genetic bottlenecks caused by pogroms (genocide) that have reduced the population multiple times in the last several hundred years.
Part A
In the population described, what is the frequency of the recessive allele that produces Tay-Sachs disease?
Part B
Assuming mating occurs at random in this population, what is the probability a couple are both carriers of Tay-Sachs disease?
Mitochondria carrying out oxidative phosphorylation consume oxygen. What happens to oxygen in mitochondria?Describe the effect of an uncoupling agent such as 2,4-dinitrophenol on the rate of oxygen consumption.
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Determine what additional data do you think is necessary for healthcare professionals and students to know? Do some additional research on the subject of laboratory safety and share your findings with your classmates and determine universal precautio..
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