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Hungtington disorder is a progressive degeneration of the nervous system that begins at middle age and results in an early death. It is caused by a single autosomal gene mutation that acts in a dominant fashion. a/ a 40 year old man was just diagnosed with Huntington disorder. What could his genotypes be? b/ His wife went for genetic screening for the Huntington allele and learned that she did not have it. What is her genotype? c/ Assume it was determined through genetic screening that the husband only had one copy of the Huntington allele. What must his genotype be? d/ Draw a Punnett square to determine their children. e/ Circle the genotypes of the children who have the HUntington allele. f/ This couple has a 12 year old son. What is the chance that he inderited the disorder? g/ Now assume it was determined through genetic screening that the husband had two copies of the Huntington allele. What must his genotype be? h/ Draw a Punnett square to determine their children. i/ Now what is the chance that the son inherited the disorder?
If you remove the ER retention signal from a protein that normally resides in the ER lumen, where do you predict the protein will ultimately end up? Explain.
If oxygen is unavailable, what happens to the citric acid cycle and if necessary, during which stage(s) of cellular respiration is(are) carbon dioxide released?
Construct-diagram a pediigree that clearly demonstrates the x-linked recessive pattern of inheritance. Use a made up trait and family history containing three generation and between 18 and 20 individuals with equal numbers of females and males in ..
you now hyperventilate for 30 seconds into and out of a paper bag. are the posthyperventilation effects any different than in question 1 ? why or why not.
Determine what can a disease like familial hypercholesterolemia tell us about the effects of cholesterol on the people without the disease?
Some malignant tumors remain localized and encapsulated, at least for a time; an illustration is carcinoma in situ in the ovary or breast. Share your thoughts to describe this phenomenon.
Describe the pathway the restores the supply of NAD+ in muscle tissue when the oxygen supply isn't adequate to meet demands. Write an equation for the process.
You measured the purified protein concentration, which is 5 ug/uL. You decided to load 20 ug protein to the gel. How would you dilute your sample?
An ER membrane protein that has an N-terminal signal sequence and a single stop transfer sequence will. Which of the following is NOT a possible target of proteins imported into the ER?
An RNA molecule has the following percentages of bases: A = 23%, U = 42%, C = 21%, and G = 14%.
What veins are most likely involved? What pathologic changes have happened in these veins, and what is the most probable cause in this patient's case.
Some dominant mutations are lethal when homozygous. Why do you think that natural selection fails to eliminate those alleles from the population?
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