What is known about mir-409 expression changes

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Reference no: EM133912575

Please give detailed answers with references in regards to to all these questions. include all references used.

1) Background on Chemotherapy Agents for Lung cancer

2) miRNA Expression Profiles (mir-409-3p expression).

3) Comparative Analysis of Drug Effects of lung cancer drugs such as etoposide and cisplatin.

5) What is Known About miR-409 Expression Changes?

6) miR-409 Expression After Etoposide/ Cisplatin Chemotherapy treatment on A549 cell lines or any other lung cancer cell line?

7) What should the IC50 value be for cisplatin/etoposide based on literature in lung cells; which concentrations are expected to be toxic; is this data available for A549 lung cancer line in literature? Is it available for other cell lines?

8) Did previous publications describe doing MTT assay or did they have a different way to establish toxicity?

9) qPCR experiment, mir-409 having a p value of 0.37 is this upregualtion or downregualtion?: what is already known about changes in expression for miRNA 409-3p? is it known how expression changes after chemotherapy? Have they used lung epithelial cells or other cells?

10) Limitations of MTT assay and qPCR?

Reference no: EM133912575

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