What is i-cell disease

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Answer these questions:

1. What specific molecular modification directs proteins to the lysosome? How is this modification restricted to just lysosomal hydrolases? How is this modification recognized, in order to transport these proteins to the lysosome

2. How can the Sec61 translocator? how it allow passage of proteins into the lumen of the endoplasmic reticulum, and how it allow passage of soon-to-be integral membrane proteins into the endoplasmic reticulum lipid bilayer?

3. What is I-cell disease? Which enzyme is often found to be mutated in this disease?

4. Based on the Nernst equation in Panel 11-1, what is the K+ equilibrium potential in milliVolts at 37°C when [K+]o = 50 mM and [K+]i = 200 mM?

5. Explain how high glucose levels trigger the secretion of insulin in beta-pancreatic cells.

Reference no: EM133984686

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