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Explain (include a diagram if you wish) how the activity of protein kinase A (PKA) is regulated by binding of cAMP. Include in your explanation:
•How the term "consensus sequence" (-RRX(S/T)Y-) relates to the activity of PKA where X is a small amino acid residue (e.g., G), and Y is a large hydrophobic residue (e.g., I), making it clear that you know how the term relates to the function and activation of PKA; •the term "pseudosubstrate sequence";
•where in the structure of PKA cAMP binds;
•what happens to the structure of PKA when cAMP binds and how that relates to PKA activity.
XPA is a recessive DNA repair disorder that causes skin cancer with even the smallest exposure to sunlight. Heterozygotes are carriers, but are not affected.
Ethylene synthesis in plants is tightly regulated and post transcriptionally controlled. Explain. Design an experiment to show that proteasome degradation is involved?
find out in which step each auxotroph has a mutaion. ("+" represents growth of the auxotroph on minimal meduim supplemented with the compund. ("-" represents no growth of the auxotroph on minimal meduim supplemented with the compound)
the best way to describe how oxidation energy is converted to ATP energy during glycolysis is by a. feedback inhibition b. allosteric conformation c. allosteric activation d. substrate-level phosphorlation.
If the seawater bathing the squid giant axon is replaced with artificial seawater in which NaCl is replaced with choline choride (which does not cross the membrane), there is no effect on membrane potential, but the axon no longer generates an act..
Epithelial tissue covers all inner and outer: A. surfaces B. spaces C. ears D. nervous systems D. any of the above could be equally valid.
Use the following data to answer the questions 1 and 2. In a sample of double-stranded DNA from a particular bacterium with a circular chromosome, 43% of the nucleotide bases are Guanine (G).
Substance X is a charged molecule of small molecular weight. It is found at higher concentrations inside of cells than outside. How might additional amouts of substance X enter cells?
Lung Cancer In the small country of Tracetonia located in the Caribbean, the population is one million people and ten percent of the countries population are smokers.
A geneticist is studying three loci, each with one dominant and one recessive allele, in a small population of rare plants. She estimates the frequencies of the alleles at each of these loci as A = 0.55 , a = 0.45; B = 0.25, b = 0.75; C = 0.80, c ..
After contact with a patient's spinal fluid, a lab technician developed fever, nausea, and purple lesions on her neck and extremities. A throat culture grew gram-negative diplococci. What is the genus of bacteria.
Nucleoplasmin is a nuclear protein. Protein was divided into two segments and linked to the same large cytoplasmic protein, generating two fusion proteins
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