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Transdermal drug delivery involves the controlled time-release of medication through the skin to the bloodstream, usually from a patch that is adhered to the body. Advantages include steady and mild drug delivery rates that reduce shock to the system as might occur with intravenous infusions, the ability to deliver medication to nauseated or unconscious patients that would be otherwise delivered in oral form, and ease of use.
Consider a square patch of length and width L = 50 mm that consists of a host medium containing an initial, uniform density of medication, pA,p,i = 100 kg/m3. The patch is applied to the skin, which contains an initial drug concentration of pA,s,i = 0. At the patch-skin interface located at x = 0, the ratio of the medication density on the patch side to the medication density on the patient side is described by a partition coefcient of K = 0.5.
A water pipe of D = 30 cm is buried in soil with a value of k = 0.52 W/mK. The center of the pipe is buried 1 meter below the surface of the ground. The surface of the ground is at -10o C.
Express the bernoulli equation in terms of pressure, head and energy in English units then in SI units with the appropriate constant and conversions factors. use algebraic ubit equations to verify that the equation is correct.
air at the rate of 18 kgs is drawn into the compressor of a jet engine at 55 kpa and -23c and is compressed reversibly
The reciprocating radial roller follower of a plate cam profile with 0.7 in offset is to rise 2 in with simple harmonic motion in 180 degrees of cam rotation and return with simple harmonic motion in the remaining 180 degrees. If the roller radius is..
Four kilograms of water, initially a saturated vapor at 75 kPa, are cooled to saturated liquid while the pressure is maintained constant. Determine the work and the heat transfer for the process, each in kJ. Show that the heat transfer equals the cha..
Determine heat flow, Heat flow through a uniform wall will: a) increase as the thermal resistance increases b) increase as the thickness of the wall increases
an industrial water shutoff valve is designed to operate with 30lbs of force and will encounter 200lbs of resistance
a cylinder fitted with a piston 10 lbm of r 134a at 100 psi and 140 f. the refrigerant is cooled at constant pressure
a heat pump maintains a dwelling at a temperature tin when the outside temperature tout is 5oc. the heat transfer heat
the rod ab slides through the pivoted collar as end a moves along the slot. if a starts from rest at x0 and moves to
A 1.00%wt Carbon steel (FCC or \gamma?Fe) axel must operate at 850C in an oxidizing environment where the carbon content at the surface of the steel is zero. Only the outermost 200 microns of the component can fall below 0.50%wt C.
if the 1500-lb boom ab the 200-lb cage bcd and the 175-lb man have centers of gravity located at points g1 g2 and g3
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