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Thermus aquaticus is a thermophilic bacterium that grows between the temperatures of 50 and 80°C. Although the signal peptide binding groove of its Ffh M domain is lined with hydrophobic groups, only three of them are Met side chains. In contrast, the binding grooves of mesophilic organisms (those that live at normal temperatures) are lined with numerous Met side chains (11 in E. coli). In addition, the finger loop forming one wall of the binding groove is disordered in the X-ray structure of the E. coli M domain but ordered in that of T. aquaticus (Figure 12-48 in Voet; both proteins were crystallized at room temperature). Suggest a reason for these evolutionary adaptations in T. aquaticus
Atherosclerosis is the progressive disease of blood vessels that is responsible for millions of death each year. Explain disease process, noting the involvement of specific cell/tissue types and molecules.
Mexican hairless dogs are heterozygous, carrying a single copy of the dominant lethal allele. In a given population, the Hh genotypic frequency is 60 percent and the frequency of each homozygote is 20 percent.
Explain the two consecutive splicing steps that result in removal of introns. Splicing fidelity relies on specific recognition of introns by the splicing machinery.
provide some information about the relationships between the intra -cellular compartments involved in the secretory and endocytic pathways,explain co-translational and post translational protein.
So far while surgery was performed on his neck, the surgeon might not find the parathyroid glands at all. Where should the surgeon look next to find out the tumorous parathyroid gland.
As exercise intensity increases, the respiratory system increases oxygen delivery to the body via the lungs by up to 10 to 20-fold.
Determine the principal reaction that makes an organic, nitrogen containing molecule, capturing the nitrogen in ammonia created through nitrogen fixation.
Assume many of the atoms of nitrogen in a double-stranded molecule of DNA, of isotope N-14, were replaced with the isotope N-15
why the sequences are read in different reading frames.
A neutral variant of feather color in snow geese, called blue phase is caused through an unknown genetic variant. The less common blue phase results from a single dominant gene while common white phase is homozygous recessive.
While the nurse applies the sharp point of the pin on his arm several times, he is only able to identify these as one "very sharp prick." What would be the most correct explanation for this.
n a folded protein, most of the nonpolar amino acids are buried inside the protein fold, whereas the polar and charged side chains are exposed to the components in the cytosol.
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