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Competitive inhibition is a strategy for controlling theactivity of an enzyme. In this mechanism and inhibitor molecule, l,binds to the active site of an enzyme, E, blocking it fromprocessing its substrate
a) Derive the Michaelis Menten rule with the idea that E cannow be in any of the 3 statesPE + PES + PEl = 1 .
b) Solve for the reaction velocity, v in terms of theuninhibited enzyme (KM & Vmax),Keq,l and the total concentrations of the inhibitor,cl and substrate cs.
c) Ethanol and methanol are 2 similar, small molecules.Methanol is quite toxic: The liver enzyme alcohol dehydrogenaseconverts it to formaldehyde, which can cause blindness (hence thedanger of drinking homemade distilled alcohol). The kidneys willeventually remove methanol from the blood, but not fast enough toavert this damage. Why do you suppose the treatment for methanolpoisoning involves gradual intravenous injection of ethanol?
Describe the changes in her total body water, intracellular fluid, plasma, and interstitial fluid levels that took place as a result of the pain, redness, and local swelling from the bee sting.
The condition known as Bell's Palsy may result in drooping of the face. Typically, the condition is unilateral but in rare instances can be bilateral.
Albanism in humans is controlled by a recessive gene (c) . Frommarriages between (Cc). Assume that such marriage (Cc x Cc) 4children are produced.
The results of any study must be interpreted cautiously so that causal inference is not extended to a population different from the study participants in important ways.
What factors contribute to membrane fluidity? List each and discuss the impact on fluidity of altering conditions on that factor in the membrane.
During exposure to elevated glucose, a yeast cell's membrane glucose transporters will rapidly increase so the cell can import glucose. Which would represent the yeast cell response.
What is a population? What is a species? You are conducting fieldwork and discover two populations of squirrels living on opposite sides of a lake. How would you design a study to determine, without disturbing the squirrels, whether these two populat..
If the gene encoding the enzyme, glycerophosphate acyl tranferase is mutated, how does this affect phospholipid metabolism?
Humans have quite a few instances of suboptimal design and evolutionary quirks. Like most animals, we vestigial structures things that evolved for specific reason at one point in our evolution,
Ornithine transcarbamoylase is a trimeric enzyme composed of identical subunits which catalyzes the synthesis of L-citrulline from carbamoyl phosphate and ornithine.
What volume of a stock solution of 200 mM ethylenediaminetetraacetic acid (EDTA), pH 7 will you use to make up 400 mL of a solution containing a final concentration of 5 mM EDTA?
describe the main causes of pituitary dysfunction and the methods used to evaluate normal/ abnormal hormone secretion- hormonal levels, feedback control and 'pituitary function' tests used in the clinic.
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