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1. An interesting to look at the role of glycosylation in influenza infection by exploring the mechanism of action of one of the only effective therapies against the virus - Tamiflu. To begin discussion ask a simple question: From a protein structure/function standpoint, what role does glycosylation play during influenza infection? What does the future have in store for NA inhibitors?
2. Reversible protein phosphorylation is a critical mediator of cellular physiology that many of you are already familiar with from your previous coursework or from last week's assignment.
What is the role of phosphorylation with respect to the Tau protein?
How does the presence of multiple phosphorylation sites complicate our understanding it's regulation (or does it?).
Keeping with our ongoing theme of protein evolution - is this a selective advantage, side effect, or something else entirely?
3. Nearly 50% of all drugs currently under modulate protein phosphorylation and the vast majority of them will fail.
Why? What is attractive about ubiquitin ligases in comparison to kinases/phosphatases with respect to drug development?
What phenomenon is responsible for the gene interaction in which one gene can interfere with the expression of another?
Suppose that several years ago you mapped two genes: A and B. You discovered that they were 12 map units apart. Since that time other analyzers have mapped several other genes
What would be the the flower colors of B_D_, B_dd, bbD_ and bbddgenotypes? In a cross of BBDD x bbdd, what would the F2 progeny phenotypicratios be?
What are the primary mechanisms the body uses to absorb carbohydrates? (i.e., transport mechanisms)?
what are the possible genotypes and phenotypes of the F2 progeny.
Suppose that the length of ten base pairs of DNA found in one turn of the helix is 34 A, what is the average length of a human chromosome in centimeters?
Give a mechanistic explanation for finding which is consistent with all the data. Explain your reasoning
q1. transformation of competent bacteria selecting for eg ampicillin-resistance 4. r select tet amps tets-e. b. gene
the circulatory system of an amphibian is divided into two separate loops. the pulmonary circulation carries
Suppose you are working for a medical device company that specializes in making fracture deviced. You are working ondeveloping a bone plate using heat treated 304 V stainless steel.If the final dimensions of the bone plate will be 40 mm in lenght..
In order to begin a research project scientists often need to create or synthesize materials that can be used in research. In thecase of true research these materials often cannot be purchased.This is the status of the research project now being u..
Compute the frequencies of the AA, Aa, and aa genotypes after one generation if the initial population consists of 0.2 AA, 0.6 Aa, and 0.2 aa genotypes
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