Reference no: EM132439822

A class of drugs, called Aromatase inhibitors, binds tightly to the enzyme responsible for estrogen synthesis, Aromatase, and inhibits estrogen synthesis in the body. One such drug, Anastrozole, is commonly used in treatment of breast cancer. Let's say, Anastrozole binds to its specific target with a high affinity, Kd of 5 nM, and to a non-specific enzyme, X, with a low affinity, Kd of 50 µM. If Anastrozole is administered to a patient at a concentration of 5 µM, how much more efficiently will Anastrozole bind to its specific target over the nonspecific target (i.e., what will be the ratio of Fractional Saturation of Aromatase versus X)?