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DNA base editors can transform a single C-G pair in a gene to a T-A pair
a) Provide a simple schematic of the structure of the base editor, mark each component and assign its functional role
b) Provide a reaction scheme for the enzymatic conversion of cytosine to uracil in the base editing process.
(c) Using a simple schematic, explain how the conversion of C to U ultimately leads to the conversion of C-G into a new T-A pair?
(d) What analytical method would you used to confirm a successful C to T conversion?
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