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Question: Early in development, most human cells turn off expression of an essential component of telomerase, the enzyme responsible for addition of telomere repeat sequences (5' TTAGGG 3') to the ends of chromosomes. Thus, as our cells proliferate, their telomeres get shorter and shorter, but are normally lost over the course of a lifetime. If cells are removed from the body and grown in culture, they ultimately enter a state of replicative senescence and stop dividing when their telomeres get too short. By contrast, most tumor cells, in humans and in cell culture, express active telomerase allowing them to maintain their telomeres and grow beyond the normal limit imposed by senescence. Anticipating a universal cure for cancer, you set up a company to screen chemical ‘libraries' for telomerase inhibitors. The company share price takes a tumble, when a rival group generates a strain of mice from which the telomerase genes have been deleted. These mice breed happily for several generations, but by the 6th generation (when their telomeres are much shorter than those of normal mice), they have a greatly increased tendency to die of tumors. The tumors tend to arise in tissues that show high proliferation rates, such as testis, skin, and blood. Why has this observation shaken the confidence of your investors? Is there a flaw in your hypothesis?
An organism is discovered that consumes a considerable amount of sugar, yet does not gain much weight when denied air. Curiously, the consumption of sugar increases as air is removed from the organism's environment, but the organism seems to thrive e..
Which of the follow is NOT a function of meiosis. Generation of genetic diversity by crossing over.
How do you find the concentration of a solution when given the info that the concentration of the stock solution is 1:57 and has a concentration of 5mg/ml.
give impact of chromosomal aberration during Meiosis II
How might you find out whether the turbidity in your nutrient broth tube was from a mixture of different microbes or from the growth of only one kind of microbe.
Degrade a monoglyceride that has an 18-carbon fatty acid attached to it by Ester bonds. You will have to degrade the glycerol component followed by the fatty acid in presence of O2.
How will you find out the transcription factor binding sites in the whole genome. You have isolated a novel transcription factor. How would you decide the genes regulated by transcription factor in the whole genome.
Industrial melanism refers to the dark pigmentation that evolved in some insects giving them protective coloration on vegetation darkened by soot in heavily industrialized areas prior to air pollution regulation.
Suppose that the length of ten base pairs of DNA found in one turn of the helix is 34 A, what is the average length of a human chromosome in centimeters?
Why can prakaryotes quickly re infect a patient if they are not wiped out? How may this result in the evolution of drug resistant pathogens.
Think about the following three mice: a gray male, a gray female, and a tan female. When the male mated with the gray female, all the offspring were gray.
Estimate how many photons of light are minimally required to build one glucose molecule in photosynthesis and describe your answer
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